Michael E Talkowski1, Heidi L Rehm2. 1. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Stanley Center for Psychiatric Research and Clinical Research Sequencing Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: mtalkowski@mgh.harvard.edu. 2. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Stanley Center for Psychiatric Research and Clinical Research Sequencing Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.