| Literature DB >> 30702286 |
Lu-Lin Xu1,2, Ping Hai3, Shuai-Bing Zhang1, Jing-Fang Xiao4, Yuan Gao3, Bing-Ji Ma5, Hai-Yan Fu1, Ye-Miao Chen4, Xiao-Long Yang1,2.
Abstract
Ten new prenylated indole diterpene alkaloids, tolypocladin A-J (1-10), including four chlorinated metabolites, have been isolated from a culture of a mine-soil-derived fungus, Tolypocladium sp. XL115. The structures and absolute configurations of 1-10 were determined by spectroscopic analysis, ECD calculations, and comparison with known compounds. Compounds 1 and 8 displayed significant antimicrobial activities. In addition, compound 1 also showed weak cytotoxic activity against all tested human cancer cell lines and suppressed the growth and viability of the patient-derived HCC cells T1224.Entities:
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Year: 2019 PMID： 30702286 DOI： 10.1021/acs.jnatprod.8b00589
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050