Literature DB >> 3069967

The potential use of mechanism-based enzyme inactivators in medicine.

R B Silverman1.   

Abstract

Mechanism-based enzyme inactivator, alanine racemase, S-adenosylhomocysteine hydrolase, D-amino acid aminotransferase, gamma-aminobutyric acid aminotransferase, arginine decarboxylase, aromatase, L-aromatic amino acid decarboxylase, dihydrofolate reductase, dihydroorotate dehydrogenase DNA polymerase I, dopamine beta-hydroxylase, histidine decarboxylase, beta-lactamase, monoamine oxidase, ornithine decarboxylase, serine proteases, testosterone 5 alpha-reductase, thymidylate synthetase, xanthine oxidase.

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Year:  1988        PMID： 3069967     DOI： 10.3109/14756368809040714

Source DB:  PubMed          Journal:  J Enzyme Inhib        ISSN： 1026-5457


  12 in total

1.  Crystallization and preliminary X-ray study of biosynthetic alanine racemase from Pseudomonas aeruginosa PAO1.

Authors:  Honggang Zhou; Zhenzhen Li; Guofang Zhang; Shujing Xu; Zhaona Tang; Xianming Zhu; Hui Dong; Jiansong Ju
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-11-14       Impact factor: 1.056

2.  Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d-Alanine Biosynthesis.

Authors:  Darrell D Marshall; Steven Halouska; Denise K Zinniel; Robert J Fenton; Katie Kenealy; Harpreet K Chahal; Govardhan Rathnaiah; Raúl G Barletta; Robert Powers
Journal:  J Proteome Res       Date:  2017-02-14       Impact factor: 4.466

3.  The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine.

Authors:  Daniel L Milligan; Sieu L Tran; Ulrich Strych; Gregory M Cook; Kurt L Krause
Journal:  J Bacteriol       Date:  2007-09-07       Impact factor: 3.490

4.  Characterization and preliminary mutation analysis of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4.

Authors:  Zhangwei Xue; Yi Hu; Shujing Xu; Kouhei Ohnishi; Yanhe Ma; Jiansong Ju; Baohua Zhao
Journal:  Extremophiles       Date:  2013-05-24       Impact factor: 2.395

5.  Inhibition of mycobacterial alanine racemase activity and growth by thiadiazolidinones.

Authors:  Yashang Lee; Sara Mootien; Carolyn Shoen; Michelle Destefano; Pier Cirillo; Oluwatoyin A Asojo; Kacheong R Yeung; Michel Ledizet; Michael H Cynamon; Paul A Aristoff; Raymond A Koski; Paul A Kaplan; Karen G Anthony
Journal:  Biochem Pharmacol       Date:  2013-05-13       Impact factor: 5.858

6.  Crystallization and preliminary X-ray study of a thermostable alanine racemase from Thermoanaerobacter tengcongensis MB4.

Authors:  Hui Dong; Shujing Xu; Xiaoyun Lu; Guangzheng He; Ranran Zhao; Shuai Chen; Sheng Fu; Jiansong Ju
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2013-05-25

Review 7.  The role of intracrine androgen metabolism, androgen receptor and apoptosis in the survival and recurrence of prostate cancer during androgen deprivation therapy.

Authors:  Michael V Fiandalo; Wenjie Wu; James L Mohler
Journal:  Curr Drug Targets       Date:  2013-04       Impact factor: 3.465

8.  Mechanism-Based Design of 3-Amino-4-Halocyclopentenecarboxylic Acids as Inactivators of GABA Aminotransferase.

Authors:  Sida Shen; Peter F Doubleday; Pathum M Weerawarna; Wei Zhu; Neil L Kelleher; Richard B Silverman
Journal:  ACS Med Chem Lett       Date:  2020-02-18       Impact factor: 4.345

9.  The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.

Authors:  Hookang Im; Miriam L Sharpe; Ulrich Strych; Milya Davlieva; Kurt L Krause
Journal:  BMC Microbiol       Date:  2011-05-25       Impact factor: 3.605

10.  Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames).

Authors:  Rafael M Couñago; Milya Davlieva; Ulrich Strych; Ryan E Hill; Kurt L Krause
Journal:  BMC Struct Biol       Date:  2009-08-20
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