| Literature DB >> 30692668 |
Amitesh Anand1, Connor A Olson1, Laurence Yang1, Anand V Sastry1, Edward Catoiu1, Kumari Sonal Choudhary1, Patrick V Phaneuf1, Troy E Sandberg1, Sibei Xu1, Ying Hefner1, Richard Szubin1, Adam M Feist1,2, Bernhard O Palsson3,4.
Abstract
Pseudogenes represent open reading frames that have been damaged by mutations, rendering the gene product non-functional. Pseudogenes are found in many genomes and are not always eliminated, even if they are potentially 'wasteful'. This raises a fundamental question about their prevalence. Here we report pseudogene efeU repair that restores the iron uptake system of Escherichia coli under a designed selection pressure during adaptive laboratory evolution.Entities:
Mesh：
Substances：
Year: 2019 PMID： 30692668 DOI： 10.1038/s41564-018-0340-2
Source DB: PubMed Journal: Nat Microbiol ISSN： 2058-5276 Impact factor: 17.745