Literature DB >> 30687853

A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins.

Samuel D Whedon1, Marissa K Parker, Elizabeth L Tyson, Tobias Ritterhoff, Patrick M M Shelton, Champak Chatterjee.   

Abstract

The Cu(i)-mediated click reaction of proteins with affinity tags enables their selective isolation from complex mixtures. However, irreversible protein modification limits the interpretation of results from subsequent biophysical and biochemical assays. We report a facile and modular chemical strategy to reversibly modify peptides and proteins with biotin and FLAG affinity tags at a clickable glutamine (CliQ) residue.

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Year:  2019        PMID： 30687853      PMCID： PMC6784325          DOI： 10.1039/c8cc09404g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  31 in total

1.  Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.

Authors:  Franziska Meier; Tharindumala Abeywardana; Abhinav Dhall; Nicholas P Marotta; Jobin Varkey; Ralf Langen; Champak Chatterjee; Matthew R Pratt
Journal:  J Am Chem Soc       Date:  2012-03-14       Impact factor: 15.419

2.  Transferase-Mediated Labeling of Protein N-Termini with Click Chemistry Handles.

Authors:  Anne M Wagner; John B Warner; Haviva E Garrett; Christopher R Walters; E James Petersson
Journal:  Methods Mol Biol       Date:  2015

3.  Traceless purification and desulfurization of tau protein ligation products.

Authors:  Oliver Reimann; Caroline Smet-Nocca; Christian P R Hackenberger
Journal:  Angew Chem Int Ed Engl       Date:  2014-11-17       Impact factor: 15.336

4.  Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex.

Authors:  Abhinav Dhall; Caroline E Weller; Aurea Chu; Patrick M M Shelton; Champak Chatterjee
Journal:  ACS Chem Biol       Date:  2017-08-30       Impact factor: 5.100

Review 5.  Chemical approaches to understand the language of histone modifications.

Authors:  Abhinav Dhall; Champak Chatterjee
Journal:  ACS Chem Biol       Date:  2011-08-17       Impact factor: 5.100

6.  A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides.

Authors:  Loay Awad; Nino Jejelava; Ritwik Burai; Hilal A Lashuel
Journal:  Chembiochem       Date:  2016-11-25       Impact factor: 3.164

Review 7.  CuAAC: An Efficient Click Chemistry Reaction on Solid Phase.

Authors:  Vida Castro; Hortensia Rodríguez; Fernando Albericio
Journal:  ACS Comb Sci       Date:  2015-12-21       Impact factor: 3.784

8.  Expressed protein ligation: a general method for protein engineering.

Authors:  T W Muir; D Sondhi; P A Cole
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

9.  Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis.

Authors:  Chris P Ryan; Mark E B Smith; Felix F Schumacher; Dina Grohmann; Danai Papaioannou; Gabriel Waksman; Finn Werner; James R Baker; Stephen Caddick
Journal:  Chem Commun (Camb)       Date:  2011-04-05       Impact factor: 6.222

10.  Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification.

Authors:  Peter Tessarz; Helena Santos-Rosa; Sam C Robson; Kathrine B Sylvestersen; Christopher J Nelson; Michael L Nielsen; Tony Kouzarides
Journal:  Nature       Date:  2013-12-18       Impact factor: 49.962
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