Literature DB >> 27788286

A New Caged-Glutamine Derivative as a Tool To Control the Assembly of Glutamine-Containing Amyloidogenic Peptides.

Loay Awad1, Nino Jejelava2, Ritwik Burai2, Hilal A Lashuel2.   

Abstract

We present the design, synthesis, and characterization of a novel photocaged glutamine derivative (modified on the side chain of glutamine), and describe its use in enhancing peptide stability and solubility. Our results demonstrate that this approach can be used to develop molecular switches to control the folding and β-sheet formation of amyloidogenic peptides.
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  amyloid beta-peptides; beta-sheet structure; neurodegenerative disease; photocleavage linker; protein folding

Mesh：

Substances：

Year:  2016        PMID： 27788286     DOI： 10.1002/cbic.201600474

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  4 in total

1.  Controlling the Oligomerization State of Aβ-Derived Peptides with Light.

Authors:  Patrick J Salveson; Sepehr Haerianardakani; Alexander Thuy-Boun; Adam G Kreutzer; James S Nowick
Journal:  J Am Chem Soc       Date:  2018-04-20       Impact factor: 15.419

2.  A clickable glutamine (CliQ) derivative for the traceless reversible modification of peptides and proteins.

Authors:  Samuel D Whedon; Marissa K Parker; Elizabeth L Tyson; Tobias Ritterhoff; Patrick M M Shelton; Champak Chatterjee
Journal:  Chem Commun (Camb)       Date:  2019-02-12       Impact factor: 6.222

3.  Synthesis of chemical tools to improve water solubility and promote the delivery of salinomycin to cancer cells.

Authors:  Loay Awad
Journal:  Exp Ther Med       Date:  2019-12-23       Impact factor: 2.447

Review 4.  The Development and Application of Opto-Chemical Tools in the Zebrafish.

Authors:  Zhiping Feng; Bertrand Ducos; Pierluigi Scerbo; Isabelle Aujard; Ludovic Jullien; David Bensimon
Journal:  Molecules       Date:  2022-09-22       Impact factor: 4.927
  4 in total

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