Monica Tous1,2, Marcela Villalobos1, Lucia Iglesias1,2, Sílvia Fernández-Barrés1,3, Victoria Arija4,5,6. 1. Research Group in Nutrition and Mental Health (NUTRISAM), Nutrition and Public Health Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, Reus, Spain. 2. Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain. 3. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. 4. Research Group in Nutrition and Mental Health (NUTRISAM), Nutrition and Public Health Unit, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, Reus, Spain. victoria.arija@urv.cat. 5. Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain. victoria.arija@urv.cat. 6. Unitat de Suport a la Recerca Tarragona-Reus, Institut Universitari d'Investigació en Atenció Primària Jordi Gol, Tarragona, Spain. victoria.arija@urv.cat.
Abstract
BACKGROUND/ OBJECTIVES: Vitamin D deficiency during pregnancy may influence adverse outcomes in offspring. The aim of this systematic review and meta-analysis of observational studies was to assess the association between low prenatal concentrations of 25(OH)D (by using three different cut-off levels), preterm birth (PTB) and anthropometric and neurodevelopmental outcomes in offspring. SUBJECTS/ METHODS: Studies reporting data on the association between maternal vitamin D concentrations and offspring outcomes identified through a systematic review of scientific literature published in PubMed/MEDLINE, Scopus and the Cochrane Library databases up to April 2017. RESULTS: We included 54 eligible studies. Vitamin D-deficient mothers (<30 nmol/L) had offspring with lower birthweight (MD -87.82 g; 95% CI -119.73, -55.91 g), head circumference (MD -0.19 cm; 95% CI -0.32, -0.06 cm) and a higher risk of small for gestational age (SGA) infants and PTB (OR 1.59; 95% CI 1.24, 2.03) compared to mothers with concentrations ≥30 nmol/L. Vitamin D insufficiency (<50 nmol/L) was associated with a higher risk of SGA and PTB (OR 1.43; 95% CI 1.08, 1.91 and OR 1.28; 95% CI 1.08, 1.52, respectively). Concentrations of 25(OH)D ≥75 nmol/L were not found to be associated with birthweight, SGA or PTB. Offspring of vitamin D-insufficient mothers had lower scores in mental (MD -1.12 points; 95% CI -1.82, -0.42 cm) and language developmental tests (MD -0.35 points; 95% CI -1.00, 0.31 cm). CONCLUSION: Maternal vitamin D deficiency is associated with offspring adverse anthropometric outcomes and PTB; insufficiency with a higher risk of SGA, PTB and adverse neurodevelopmental outcomes.
BACKGROUND/ OBJECTIVES: Vitamin D deficiency during pregnancy may influence adverse outcomes in offspring. The aim of this systematic review and meta-analysis of observational studies was to assess the association between low prenatal concentrations of 25(OH)D (by using three different cut-off levels), preterm birth (PTB) and anthropometric and neurodevelopmental outcomes in offspring. SUBJECTS/ METHODS: Studies reporting data on the association between maternal vitamin D concentrations and offspring outcomes identified through a systematic review of scientific literature published in PubMed/MEDLINE, Scopus and the Cochrane Library databases up to April 2017. RESULTS: We included 54 eligible studies. Vitamin D-deficient mothers (<30 nmol/L) had offspring with lower birthweight (MD -87.82 g; 95% CI -119.73, -55.91 g), head circumference (MD -0.19 cm; 95% CI -0.32, -0.06 cm) and a higher risk of small for gestational age (SGA) infants and PTB (OR 1.59; 95% CI 1.24, 2.03) compared to mothers with concentrations ≥30 nmol/L. Vitamin D insufficiency (<50 nmol/L) was associated with a higher risk of SGA and PTB (OR 1.43; 95% CI 1.08, 1.91 and OR 1.28; 95% CI 1.08, 1.52, respectively). Concentrations of 25(OH)D ≥75 nmol/L were not found to be associated with birthweight, SGA or PTB. Offspring of vitamin D-insufficient mothers had lower scores in mental (MD -1.12 points; 95% CI -1.82, -0.42 cm) and language developmental tests (MD -0.35 points; 95% CI -1.00, 0.31 cm). CONCLUSION: Maternal vitamin D deficiency is associated with offspring adverse anthropometric outcomes and PTB; insufficiency with a higher risk of SGA, PTB and adverse neurodevelopmental outcomes.
Authors: P Lips; D Hosking; K Lippuner; J M Norquist; L Wehren; G Maalouf; S Ragi-Eis; J Chandler Journal: J Intern Med Date: 2006-09 Impact factor: 8.989
Authors: Natalia Perez-Ferre; Maria José Torrejon; Manuel Fuentes; Maria Dolores Fernandez; Ana Ramos; Elena Bordiu; Laura del Valle; Miguel A Rubio; Ana R Bedia; Carmen Montañez; Alfonso L Calle-Pascual Journal: Endocr Pract Date: 2012 Sep-Oct Impact factor: 3.443
Authors: Heather H Burris; Sheryl L Rifas-Shiman; Carlos A Camargo; Augusto A Litonjua; Susanna Y Huh; Janet W Rich-Edwards; Matthew W Gillman Journal: Ann Epidemiol Date: 2012-06-01 Impact factor: 3.797
Authors: Veronica T Boyle; Eric B Thorstensen; David Mourath; M Beatrix Jones; Lesley M E McCowan; Louise C Kenny; Philip N Baker Journal: Br J Nutr Date: 2016-10-18 Impact factor: 3.718
Authors: Kozeta Miliku; Anna Vinkhuyzen; Laura Me Blanken; John J McGrath; Darryl W Eyles; Thomas H Burne; Albert Hofman; Henning Tiemeier; Eric Ap Steegers; Romy Gaillard; Vincent Wv Jaddoe Journal: Am J Clin Nutr Date: 2016-04-20 Impact factor: 7.045
Authors: Catherine S Birken; Jessica A Omand; Kim M Nurse; Cornelia M Borkhoff; Christine Koroshegyi; Gerald Lebovic; Jonathon L Maguire; Muhammad Mamdani; Patricia C Parkin; Janis Randall Simpson; Mark S Tremblay; Eric Duku; Caroline Reid-Westoby; Magdalena Janus Journal: BMJ Open Date: 2019-11-19 Impact factor: 2.692
Authors: Aishwarya P Yadama; Hooman Mirzakhani; Thomas F McElrath; Augusto A Litonjua; Scott T Weiss Journal: PLoS One Date: 2020-01-29 Impact factor: 3.240