BACKGROUND: Maternal vitamin D status in pregnancy is linked to foetal growth and may impact infant growth. AIM: This study examined the association between maternal vitamin D status and infant anthropometry. SUBJECTS AND METHODS: Data came from n = 2473 mother-child pairs from the 12-site US Collaborative Perinatal Project (1959-1965). Maternal serum 25-hydroxyvitamin D (25(OH)D) was measured at ≤ 26 weeks gestation. Multivariate-adjusted linear mixed models were used to relate maternal vitamin D status to infant z-scores for length (LAZ), head circumference (HCZ), weight (WAZ) and BMI (BMIZ), measured at birth and 4, 8 and 12 months. RESULTS: Infants with maternal 25(OH)D ≥30 nmol/L vs <30 nmol/L had LAZ and HCZ measures 0.13 (95% CI = 0.03-0.23) and 0.20 (95% CI = 0.11-0.28) units higher, respectively, across the first year of life. Similar differences in WAZ and BMIZ at birth were resolved by 12 months of age due to interactions indicating steeper age slopes in infants with maternal 25(OH)D <30 nmol/L. CONCLUSION: Low maternal vitamin D status was associated with deficits at birth in infant weight and BMI that were recouped across the first year of life; associations with reduced measures of linear and skeletal growth were sustained from birth to 12 months.
BACKGROUND: Maternal vitamin D status in pregnancy is linked to foetal growth and may impact infant growth. AIM: This study examined the association between maternal vitamin D status and infant anthropometry. SUBJECTS AND METHODS: Data came from n = 2473 mother-child pairs from the 12-site US Collaborative Perinatal Project (1959-1965). Maternal serum 25-hydroxyvitamin D (25(OH)D) was measured at ≤ 26 weeks gestation. Multivariate-adjusted linear mixed models were used to relate maternal vitamin D status to infant z-scores for length (LAZ), head circumference (HCZ), weight (WAZ) and BMI (BMIZ), measured at birth and 4, 8 and 12 months. RESULTS:Infants with maternal 25(OH)D ≥30 nmol/L vs <30 nmol/L had LAZ and HCZ measures 0.13 (95% CI = 0.03-0.23) and 0.20 (95% CI = 0.11-0.28) units higher, respectively, across the first year of life. Similar differences in WAZ and BMIZ at birth were resolved by 12 months of age due to interactions indicating steeper age slopes in infants with maternal 25(OH)D <30 nmol/L. CONCLUSION: Low maternal vitamin D status was associated with deficits at birth in infant weight and BMI that were recouped across the first year of life; associations with reduced measures of linear and skeletal growth were sustained from birth to 12 months.
Authors: Mercedes de Onis; Cutberto Garza; Cesar G Victora; Adelheid W Onyango; Edward A Frongillo; Jose Martines Journal: Food Nutr Bull Date: 2004-03 Impact factor: 2.069
Authors: Christopher R Sudfeld; Denise L Jacobson; Noé M Rueda; Daniela Neri; Armando J Mendez; Laurie Butler; Suzanne Siminski; Kristy M Hendricks; Claude A Mellins; Christopher P Duggan; Tracie L Miller Journal: J Acquir Immune Defic Syndr Date: 2019-07-01 Impact factor: 3.731
Authors: Folami Y Ideraabdullah; Anthony M Belenchia; Cheryl Susan Rosenfeld; Seth W Kullman; Megan Knuth; Debrata Mahapatra; Michael Bereman; Edward D Levin; Catherine Ann Peterson Journal: J Endocrinol Date: 2019-03-01 Impact factor: 4.286
Authors: Claire Casey; Ann McGinty; Valerie A Holmes; Chris C Patterson; Ian S Young; David R McCance Journal: Br J Nutr Date: 2018-07 Impact factor: 3.718
Authors: Daniel E Roth; Alison D Gernand; Shaun K Morris; Brendon Pezzack; M Munirul Islam; Michelle C Dimitris; Shaila S Shanta; Stanley H Zlotkin; Andrew R Willan; Tahmeed Ahmed; Prakesh S Shah; Kellie E Murphy; Rosanna Weksberg; Sanaa Choufani; Rashed Shah; Abdullah Al Mahmud Journal: Trials Date: 2015-07-14 Impact factor: 2.279
Authors: Yi Lin Ong; Phaik Ling Quah; Mya Thway Tint; Izzuddin M Aris; Ling Wei Chen; Rob M van Dam; Denise Heppe; Seang-Mei Saw; Keith M Godfrey; Peter D Gluckman; Yap Seng Chong; Fabian Yap; Yung Seng Lee; Mary Foong-Fong Chong Journal: Br J Nutr Date: 2016-06-24 Impact factor: 3.718
Authors: Julia Knabl; Aurelia Vattai; Yao Ye; Julia Jueckstock; Stefan Hutter; Franz Kainer; Sven Mahner; Udo Jeschke Journal: Int J Mol Sci Date: 2017-11-06 Impact factor: 5.923