Neeta Thakur1, Luisa N Borrell2, Morgan Ye3, Sam S Oh3, Celeste Eng3, Kelley Meade4, Pedro C Avila5, Harold J Farber6, Denise Serebrisky7, Emerita Brigino-Buenaventura8, William Rodriguez-Cintron9, Rajesh Kumar10, Kirsten Bibbins-Domingo3, Shannon Thyne11, Saunak Sen12, Jose R Rodriguez-Santana13, Esteban G Burchard14. 1. Department of Medicine, University of California, San Francisco, Calif. Electronic address: Neeta.Thakur@ucsf.edu. 2. Department of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, NY. 3. Department of Medicine, University of California, San Francisco, Calif. 4. Children's Hospital and Research Center Oakland, Oakland, Calif. 5. Allergy ENT & Associates, Woodlands, Tex. 6. Department of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex. 7. Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY. 8. Department of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, Calif. 9. Veterans Caribbean Health Care System, San Juan, Puerto Rico. 10. Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill. 11. Department of Pediatrics, University of California, Los Angeles, Calif. 12. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tenn. 13. Centro de Neumología Pediátrica, San Juan, Puerto Rico. 14. Department of Medicine, University of California, San Francisco, Calif; Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, Calif.
Abstract
BACKGROUND: Acculturation is an important predictor of asthma in Latino youth, specifically Mexican Americans. Less is known about acculturation and pulmonary function measures. OBJECTIVE: We sought to estimate the association of acculturation measures with asthma and pulmonary function in Latino youth and determine whether this association varies across Latino subgroups. METHODS: We included 1849 Latinos (302 Caribbean Spanish, 193 Central or South Americans, 1136 Mexican Americans, and 218 other Latino children) aged 8 to 21 years from 4 urban regions in the United States. Acculturation measures include nativity status, age of immigration, language of preference, and generation in the United States. We used multivariable logistic and linear regression models to quantify the association of acculturation factors with the presence of asthma (case-control study) and pulmonary function (case-only study), adjusting for demographic, socioenvironmental, and clinical variables. RESULTS: For all acculturation measures (nativity status, age of immigration, language of preference, and generation in the United States), greater levels of acculturation were associated with greater odds of asthma. Among cases, high (English preference) and medium (equal preference for Spanish and English) levels of language acculturation were associated with decreased bronchodilator response compared with low (Spanish preference) levels (P = .009 and .02, respectively). Similarly, high language acculturation was associated with increased FEV1 compared with low language acculturation (P = .02). There was insufficient evidence of heterogeneity for associations across Latino subgroups. CONCLUSIONS: Acculturation was associated with diagnosed asthma and pulmonary function in Latino children and is an important factor to consider in the management of Latino youth with asthma.
BACKGROUND: Acculturation is an important predictor of asthma in Latino youth, specifically Mexican Americans. Less is known about acculturation and pulmonary function measures. OBJECTIVE: We sought to estimate the association of acculturation measures with asthma and pulmonary function in Latino youth and determine whether this association varies across Latino subgroups. METHODS: We included 1849 Latinos (302 Caribbean Spanish, 193 Central or South Americans, 1136 Mexican Americans, and 218 other Latino children) aged 8 to 21 years from 4 urban regions in the United States. Acculturation measures include nativity status, age of immigration, language of preference, and generation in the United States. We used multivariable logistic and linear regression models to quantify the association of acculturation factors with the presence of asthma (case-control study) and pulmonary function (case-only study), adjusting for demographic, socioenvironmental, and clinical variables. RESULTS: For all acculturation measures (nativity status, age of immigration, language of preference, and generation in the United States), greater levels of acculturation were associated with greater odds of asthma. Among cases, high (English preference) and medium (equal preference for Spanish and English) levels of language acculturation were associated with decreased bronchodilator response compared with low (Spanish preference) levels (P = .009 and .02, respectively). Similarly, high language acculturation was associated with increased FEV1 compared with low language acculturation (P = .02). There was insufficient evidence of heterogeneity for associations across Latino subgroups. CONCLUSIONS: Acculturation was associated with diagnosed asthma and pulmonary function in Latino children and is an important factor to consider in the management of Latino youth with asthma.
Authors: Neeta Thakur; Sam S Oh; Elizabeth A Nguyen; Melissa Martin; Lindsey A Roth; Joshua Galanter; Christopher R Gignoux; Celeste Eng; Adam Davis; Kelley Meade; Michael A LeNoir; Pedro C Avila; Harold J Farber; Denise Serebrisky; Emerita Brigino-Buenaventura; William Rodriguez-Cintron; Rajesh Kumar; L Keoki Williams; Kirsten Bibbins-Domingo; Shannon Thyne; Saunak Sen; Jose R Rodriguez-Santana; Luisa N Borrell; Esteban G Burchard Journal: Am J Respir Crit Care Med Date: 2013-11-15 Impact factor: 21.405
Authors: John M Brehm; Sima K Ramratnam; Sze Man Tse; Damien C Croteau-Chonka; Maria Pino-Yanes; Christian Rosas-Salazar; Augusto A Litonjua; Benjamin A Raby; Nadia Boutaoui; Yueh-Ying Han; Wei Chen; Erick Forno; Anna L Marsland; Nicole R Nugent; Celeste Eng; Angel Colón-Semidey; María Alvarez; Edna Acosta-Pérez; Melissa L Spear; Fernando D Martinez; Lydiana Avila; Scott T Weiss; Manuel Soto-Quiros; Carole Ober; Dan L Nicolae; Kathleen C Barnes; Robert F Lemanske; Robert C Strunk; Andrew Liu; Stephanie J London; Frank Gilliland; Patrick Sleiman; Michael March; Hakon Hakonarson; Qing Ling Duan; Jay K Kolls; Gregory K Fritz; Donglei Hu; Negar Fani; Jennifer S Stevens; Lynn M Almli; Esteban G Burchard; Jaemin Shin; Elizabeth L McQuaid; Kerry Ressler; Glorisa Canino; Juan C Celedón Journal: Am J Respir Crit Care Med Date: 2015-07-01 Impact factor: 21.405
Authors: Katherine K Nishimura; Joshua M Galanter; Lindsey A Roth; Sam S Oh; Neeta Thakur; Elizabeth A Nguyen; Shannon Thyne; Harold J Farber; Denise Serebrisky; Rajesh Kumar; Emerita Brigino-Buenaventura; Adam Davis; Michael A LeNoir; Kelley Meade; William Rodriguez-Cintron; Pedro C Avila; Luisa N Borrell; Kirsten Bibbins-Domingo; Jose R Rodriguez-Santana; Śaunak Sen; Fred Lurmann; John R Balmes; Esteban G Burchard Journal: Am J Respir Crit Care Med Date: 2013-08-01 Impact factor: 21.405
Authors: Maria Pino-Yanes; Neeta Thakur; Christopher R Gignoux; Joshua M Galanter; Lindsey A Roth; Celeste Eng; Katherine K Nishimura; Sam S Oh; Hita Vora; Scott Huntsman; Elizabeth A Nguyen; Donglei Hu; Katherine A Drake; David V Conti; Andres Moreno-Estrada; Karla Sandoval; Cheryl A Winkler; Luisa N Borrell; Fred Lurmann; Talat S Islam; Adam Davis; Harold J Farber; Kelley Meade; Pedro C Avila; Denise Serebrisky; Kirsten Bibbins-Domingo; Michael A Lenoir; Jean G Ford; Emerita Brigino-Buenaventura; William Rodriguez-Cintron; Shannon M Thyne; Saunak Sen; Jose R Rodriguez-Santana; Carlos D Bustamante; L Keoki Williams; Frank D Gilliland; W James Gauderman; Rajesh Kumar; Dara G Torgerson; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2014-10-06 Impact factor: 10.793
Authors: Aaron Baugh; Russell G Buhr; Pedro Quibrera; Igor Barjaktarevic; R Graham Barr; Russell Bowler; Meilan King Han; Joel D Kaufman; Abigail L Koch; Jerry Krishnan; Wassim Labaki; Fernando J Martinez; Takudzwa Mkorombindo; Andrew Namen; Victor Ortega; Robert Paine; Stephen P Peters; Helena Schotland; Krishna Sundar; Michelle R Zeidler; Nadia N Hansel; Prescott G Woodruff; Neeta Thakur Journal: Sleep Date: 2022-08-11 Impact factor: 6.313
Authors: John Heintzman; David Ezekiel-Herrera; Steffani R Bailey; Arvin Garg; Jennifer Lucas; Shakira Suglia; Stuart Cowburn; Jon Puro; Miguel Marino Journal: J Asthma Date: 2020-12-18 Impact factor: 2.515