Maria Pino-Yanes1, Neeta Thakur2, Christopher R Gignoux3, Joshua M Galanter4, Lindsey A Roth2, Celeste Eng2, Katherine K Nishimura2, Sam S Oh2, Hita Vora5, Scott Huntsman2, Elizabeth A Nguyen2, Donglei Hu2, Katherine A Drake3, David V Conti5, Andres Moreno-Estrada6, Karla Sandoval6, Cheryl A Winkler7, Luisa N Borrell8, Fred Lurmann9, Talat S Islam5, Adam Davis10, Harold J Farber11, Kelley Meade10, Pedro C Avila12, Denise Serebrisky13, Kirsten Bibbins-Domingo14, Michael A Lenoir15, Jean G Ford16, Emerita Brigino-Buenaventura17, William Rodriguez-Cintron18, Shannon M Thyne19, Saunak Sen20, Jose R Rodriguez-Santana21, Carlos D Bustamante6, L Keoki Williams22, Frank D Gilliland5, W James Gauderman5, Rajesh Kumar23, Dara G Torgerson2, Esteban G Burchard4. 1. Department of Medicine, University of California, San Francisco (UCSF), San Francisco, Calif; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mdelpino@ull.edu.es. 2. Department of Medicine, University of California, San Francisco (UCSF), San Francisco, Calif. 3. Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, Calif. 4. Department of Medicine, University of California, San Francisco (UCSF), San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, UCSF, San Francisco, Calif. 5. Department of Preventative Medicine, University of Southern California, Los Angeles, Calif. 6. Department of Genetics, Stanford University, Palo Alto, Calif. 7. Basic Research Laboratory, SAIC-Frederick, Inc, Center for Cancer Research, National Cancer Institute, Frederick, Md. 8. Department of Health Sciences, Graduate Program in Public Health, City University of New York, Bronx, NY. 9. Sonoma Technology, Inc, Petaluma, Calif. 10. Children's Hospital and Research Center Oakland, Oakland, Calif. 11. Department of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex. 12. Department of Medicine, Northwestern University, Chicago, Ill. 13. Pediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY. 14. Division of General Internal Medicine, UCSF, San Francisco, Calif. 15. Bay Area Pediatrics, Oakland, Calif. 16. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. 17. Department of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, Calif. 18. Veterans Caribbean Health Care System, San Juan, Puerto Rico. 19. Department of Pediatrics, UCSF, San Francisco General Hospital, San Francisco, Calif. 20. Department of Epidemiology and Biostatistics, UCSF, San Francisco, Calif. 21. Centro de Neumología Pediátrica, San Juan, Puerto Rico. 22. Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Mich; Department of Internal Medicine, Henry Ford Health System, Detroit, Mich. 23. Children's Memorial Hospital and the Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Abstract
BACKGROUND: Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest. OBJECTIVE: To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children. METHODS: We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry. RESULTS: Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10(-15)), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P = .001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10(-5) and -83 ± 19 mL; P = 1.1 x 10(-5), respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10(-6) and -107 ± 22 mL; P = 1.0 x 10(-6), respectively). CONCLUSION: Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.
BACKGROUND:Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest. OBJECTIVE: To determine whether genetic ancestry is associated with the odds of asthma among Latinos, and secondarily whether genetic ancestry is associated with lung function among Latino children. METHODS: We analyzed 5493 Latinos with and without asthma from 3 independent studies. For each participant, we estimated the proportion of African, European, and Native American ancestry using genome-wide data. We tested whether genetic ancestry was associated with the presence of asthma and lung function among subjects with and without asthma. Odds ratios (OR) and effect sizes were assessed for every 20% increase in each ancestry. RESULTS: Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P = 8.0 × 10(-15)), while African ancestry was associated with higher odds of asthma (OR = 1.40, 95% CI: 1.14-1.72, P = .001). These associations were robust to adjustment for covariates related to early life exposures, air pollution, and socioeconomic status. Among children with asthma, African ancestry was associated with lower lung function, including both pre- and post-bronchodilator measures of FEV1 (-77 ± 19 mL; P = 5.8 × 10(-5) and -83 ± 19 mL; P = 1.1 x 10(-5), respectively) and forced vital capacity (-100 ± 21 mL; P = 2.7 × 10(-6) and -107 ± 22 mL; P = 1.0 x 10(-6), respectively). CONCLUSION: Differences in the proportions of genetic ancestry can partially explain disparities in asthma susceptibility and lung function among Latinos.
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