Enrico Heffler1, Claudia Crimi2, Raffaele Campisi3, Stefania Sichili3, Giuliana Nicolosi3, Morena Porto3, Rossella Intravaia3, Maria Eva Sberna3, Maria Teresa Liuzzo3, Nunzio Crimi3. 1. Respiratory Medicine and Allergology, Department of Clinical and Experimental Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Italy. Electronic address: heffler.enrico@gmail.com. 2. Respiratory Intensive Care Unit, Cannizzaro Hospital, Catania, Italy. 3. Respiratory Medicine and Allergology, Department of Clinical and Experimental Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Italy.
Abstract
BACKGROUND: Asthma guidelines emphasise the importance of monitoring disease control in managing asthma. OBJECTIVE: The aim of this study was to evaluate the relationship between lung function, including bronchodilator response in terms of improving in FEV1 after administration of salbutamol, and asthma control. METHODS: 246 patients with known asthma and in regular chronic treatment according to international guidelines were consecutively enrolled in a 12 month-period. All patients were evaluated by asthma control test (ACT), spirometry and bronchodilator test with salbutamol 400 mcg. RESULTS: Mean ACT value was 18.8. Patients with significant bronchial reversibility had lower ACT mean values. This finding was confirmed in both patients with airway obstruction and in those with normal spirometry. There was a significant correlation between ACT values and bronchodilator response. CONCLUSIONS: The persistence of a significant degree of bronchodilator response despite regular treatment according to guidelines was a marker of worse asthma control. CLINICAL IMPLICATIONS: Bronchodilator response, correlating with worse asthma control even in patients with normal spirometry, should be test at every visit as it may add information on asthma control.
BACKGROUND: Asthma guidelines emphasise the importance of monitoring disease control in managing asthma. OBJECTIVE: The aim of this study was to evaluate the relationship between lung function, including bronchodilator response in terms of improving in FEV1 after administration of salbutamol, and asthma control. METHODS: 246 patients with known asthma and in regular chronic treatment according to international guidelines were consecutively enrolled in a 12 month-period. All patients were evaluated by asthma control test (ACT), spirometry and bronchodilator test with salbutamol 400 mcg. RESULTS: Mean ACT value was 18.8. Patients with significant bronchial reversibility had lower ACT mean values. This finding was confirmed in both patients with airway obstruction and in those with normal spirometry. There was a significant correlation between ACT values and bronchodilator response. CONCLUSIONS: The persistence of a significant degree of bronchodilator response despite regular treatment according to guidelines was a marker of worse asthma control. CLINICAL IMPLICATIONS: Bronchodilator response, correlating with worse asthma control even in patients with normal spirometry, should be test at every visit as it may add information on asthma control.
Authors: Alice M Cottee; Leigh M Seccombe; Cindy Thamrin; Gregory G King; Matthew J Peters; Claude S Farah Journal: Chest Date: 2020-01-23 Impact factor: 9.410
Authors: Joo Hee Kim; Young Sook Jang; Hwan Il Kim; Ji Young Park; Sung Hoon Park; Yong Il Hwang; Seung Hun Jang; Ki Suck Jung; Hae Sim Park; Choon Sik Park Journal: Allergy Asthma Immunol Res Date: 2020-07 Impact factor: 5.764
Authors: Neeta Thakur; Luisa N Borrell; Morgan Ye; Sam S Oh; Celeste Eng; Kelley Meade; Pedro C Avila; Harold J Farber; Denise Serebrisky; Emerita Brigino-Buenaventura; William Rodriguez-Cintron; Rajesh Kumar; Kirsten Bibbins-Domingo; Shannon Thyne; Saunak Sen; Jose R Rodriguez-Santana; Esteban G Burchard Journal: J Allergy Clin Immunol Date: 2019-01-22 Impact factor: 14.290