Literature DB >> 30679221

Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI.

R Watts1, J M Steinklein2, L Waldman2, X Zhou2, C G Filippi3.   

Abstract

On the basis of animal models, glymphatic flow disruption is hypothesized to be a factor in the development of Alzheimer's disease. We report the first quantitative study of glymphatic flow in man, combining intrathecal administration of gadobutrol with serial T1 mapping to produce contrast concentration maps up to 3 days postinjection, demonstrating performing a quantitative study using the techniques described feasibility and providing data on pharmacokinetics.
© 2019 by American Journal of Neuroradiology.

Entities:  

Year:  2019        PMID： 30679221      PMCID： PMC7048502          DOI： 10.3174/ajnr.A5931

Source DB:  PubMed          Journal:  AJNR Am J Neuroradiol        ISSN： 0195-6108            Impact factor:   3.825


  16 in total

1.  Rapid high-resolution T(1) mapping by variable flip angles: accurate and precise measurements in the presence of radiofrequency field inhomogeneity.

Authors:  Hai-Ling Margaret Cheng; Graham A Wright
Journal:  Magn Reson Med       Date:  2006-03       Impact factor: 4.668

2.  Brain-wide pathway for waste clearance captured by contrast-enhanced MRI.

Authors:  Jeffrey J Iliff; Hedok Lee; Mei Yu; Tian Feng; Jean Logan; Maiken Nedergaard; Helene Benveniste
Journal:  J Clin Invest       Date:  2013-02-22       Impact factor: 14.808

3.  Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T.

Authors:  Hedok Lee; Kristian Mortensen; Simon Sanggaard; Palle Koch; Hans Brunner; Bjørn Quistorff; Maiken Nedergaard; Helene Benveniste
Journal:  Magn Reson Med       Date:  2017-06-19       Impact factor: 4.668

4.  Intrathecal gadolinium-enhanced MR cisternography in patients with otorhinorrhea: 10-year experience of a tertiary referral center.

Authors:  Sebahat Nacar Dogan; Osman Kizilkilic; Burak Kocak; Cihan Isler; Civan Islak; Naci Kocer
Journal:  Neuroradiology       Date:  2018-03-23       Impact factor: 2.804

5.  Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy.

Authors:  Cheryl A Hawkes; Wolfgang Härtig; Johannes Kacza; Reinhard Schliebs; Roy O Weller; James A Nicoll; Roxana O Carare
Journal:  Acta Neuropathol       Date:  2011-01-23       Impact factor: 17.088

6.  Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.

Authors:  Jeffrey J Iliff; Michael J Chen; Benjamin A Plog; Douglas M Zeppenfeld; Melissa Soltero; Lijun Yang; Itender Singh; Rashid Deane; Maiken Nedergaard
Journal:  J Neurosci       Date:  2014-12-03       Impact factor: 6.167

Review 7.  Protein aggregation and neurodegenerative disease.

Authors:  Christopher A Ross; Michelle A Poirier
Journal:  Nat Med       Date:  2004-07       Impact factor: 53.440

8.  Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study.

Authors:  Per K Eide; Geir Ringstad
Journal:  J Cereb Blood Flow Metab       Date:  2018-02-27       Impact factor: 6.200

9.  MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain.

Authors:  Per Kristian Eide; Geir Ringstad
Journal:  Acta Radiol Open       Date:  2015-11-17

Review 10.  Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases.

Authors:  Erik N T P Bakker; Brian J Bacskai; Michal Arbel-Ornath; Roxana Aldea; Beatrice Bedussi; Alan W J Morris; Roy O Weller; Roxana O Carare
Journal:  Cell Mol Neurobiol       Date:  2016-03-18       Impact factor: 5.046
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  24 in total

1.  Quantitative imaging of the clearance systems in the eye and the brain.

Authors:  Wenyu Deng; Crystal Liu; Carlos Parra; Jeffrey R Sims; Muneeb A Faiq; Anoop Sainulabdeen; Hana Song; Kevin C Chan
Journal:  Quant Imaging Med Surg       Date:  2020-01

2.  Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients.

Authors:  C S Edeklev; M Halvorsen; G Løvland; S A S Vatnehol; Ø Gjertsen; B Nedregaard; R Sletteberg; G Ringstad; P K Eide
Journal:  AJNR Am J Neuroradiol       Date:  2019-07-18       Impact factor: 3.825

3.  The role of the parenchymal vascular system in cerebrospinal fluid tracer clearance.

Authors:  Jiani Hu; Yimin Shen; Lara M Fahmy; Satish Krishnamurthy; Jie Li; Li Zhang; Yongsheng Chen; E Mark Haacke; Quan Jiang
Journal:  Eur Radiol       Date:  2022-07-19       Impact factor: 7.034

Review 4.  The glymphatic system: implications for drugs for central nervous system diseases.

Authors:  Terhi J Lohela; Tuomas O Lilius; Maiken Nedergaard
Journal:  Nat Rev Drug Discov       Date:  2022-08-10       Impact factor: 112.288

5.  Choroid plexus perfusion and intracranial cerebrospinal fluid changes after angiogenesis.

Authors:  Skylar E Johnson; Colin D McKnight; Sarah K Lants; Meher R Juttukonda; Matthew Fusco; Rohan Chitale; Paula C Donahue; Daniel O Claassen; Manus J Donahue
Journal:  J Cereb Blood Flow Metab       Date:  2019-09-09       Impact factor: 6.200

Review 6.  Fluid transport in the brain.

Authors:  Martin Kaag Rasmussen; Humberto Mestre; Maiken Nedergaard
Journal:  Physiol Rev       Date:  2021-05-05       Impact factor: 37.312

Review 7.  Waste Clearance in the Brain.

Authors:  Jasleen Kaur; Lara M Fahmy; Esmaeil Davoodi-Bojd; Li Zhang; Guangliang Ding; Jiani Hu; Zhenggang Zhang; Michael Chopp; Quan Jiang
Journal:  Front Neuroanat       Date:  2021-07-07       Impact factor: 3.856

Review 8.  Advances in translational imaging of the microcirculation.

Authors:  Marie Guerraty; Akanksha Bhargava; Janaka Senarathna; Asher A Mendelson; Arvind P Pathak
Journal:  Microcirculation       Date:  2021-03-13       Impact factor: 2.679

Review 9.  Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging.

Authors:  Helene Benveniste; Hedok Lee; Burhan Ozturk; Xinan Chen; Sunil Koundal; Paul Vaska; Allen Tannenbaum; Nora D Volkow
Journal:  Neuroscience       Date:  2020-11-26       Impact factor: 3.708

Review 10.  Perivascular spaces in the brain: anatomy, physiology and pathology.

Authors:  Joanna M Wardlaw; Helene Benveniste; Maiken Nedergaard; Berislav V Zlokovic; Humberto Mestre; Hedok Lee; Fergus N Doubal; Rosalind Brown; Joel Ramirez; Bradley J MacIntosh; Allen Tannenbaum; Lucia Ballerini; Ravi L Rungta; Davide Boido; Melanie Sweeney; Axel Montagne; Serge Charpak; Anne Joutel; Kenneth J Smith; Sandra E Black
Journal:  Nat Rev Neurol       Date:  2020-02-24       Impact factor: 42.937
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