Jing-Wen Yang1, Guang-Xia Shi2, Shuai Zhang1, Jian-Feng Tu2, Li-Qiong Wang1, Chao-Qun Yan1, Lu-Lu Lin1, Bao-Zhen Liu3, Jun Wang4, San-Feng Sun3, Bo-Feng Yang1, Li-Yu Wu3, Cheng Tan4, Sheng Chen4, Zhang-Jin Zhang5, Marc Fisher6, Cun-Zhi Liu1. 1. 1 Department of Acupuncture and Moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. 2. 2 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, Beijing, China. 3. 3 Department of Acupuncture and Moxibustion, Beijing Huairou District Hospital of Traditional Chinese Medicine, Beijing, China. 4. 4 Department of Acupuncture and Moxibustion, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China. 5. 5 School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong. 6. 6 Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Abstract
OBJECTIVE: : To evaluate the effectiveness of acupuncture in patients with vascular cognitive impairmentno dementia (VCIND) in comparison with citicoline, an agent for cognitive disturbances associated with chronic cerebral disorders. DESIGN: : A randomized controlled multicenter trial. SETTING: : In three hospitals in Beijing, China. SUBJECTS: : A total of 216 patients with VCIND were recruited. INTERVENTIONS: : Patients with VCIND (mean age of 65.4 years) were randomized to receive acupuncture (two sessions per week) or oral citicoline (100 mg three times daily) over three months. MAIN MEASURES:: The primary outcome was the change from baseline to three months in cognitive symptom, measured by Alzheimer's disease Assessment Scale, cognitive subscale (ADAS-cog). Secondary outcomes included changes from baseline to six months in ADAS-cog, executive function measured by the Clock Drawing Test (CDT), and functional disability measured by the Ability of Daily Living (ADL) scale at three and six months. RESULTS: : At three months, the acupuncture group had a greater decrease in mean ADAS-cog score (-2.33 ± 0.31) than the citicoline group (-1.38 ± 0.34) with a mean difference of -0.95 (95% CI, -1.84 to -0.07, P = 0.035). The mean change from baseline to six months in ADAS-cog also significantly favored acupuncture treatments (acupuncture change -2.61 vs citicoline -1.25, difference: -1.36 points; 95% CI, -2.20 to -0.51; P = 0.002). There was no difference between the two groups on CDT and ADL scores at either time point. CONCLUSION: : Compared with citicoline, acupuncture has comparable and even superior efficacy with improved cognitive and daily living performance as a complementary and alternative medicine treatment for VCIND.
RCT Entities:
OBJECTIVE: : To evaluate the effectiveness of acupuncture in patients with vascular cognitive impairment no dementia (VCIND) in comparison with citicoline, an agent for cognitive disturbances associated with chronic cerebral disorders. DESIGN: : A randomized controlled multicenter trial. SETTING: : In three hospitals in Beijing, China. SUBJECTS: : A total of 216 patients with VCIND were recruited. INTERVENTIONS: : Patients with VCIND (mean age of 65.4 years) were randomized to receive acupuncture (two sessions per week) or oral citicoline (100 mg three times daily) over three months. MAIN MEASURES:: The primary outcome was the change from baseline to three months in cognitive symptom, measured by Alzheimer's disease Assessment Scale, cognitive subscale (ADAS-cog). Secondary outcomes included changes from baseline to six months in ADAS-cog, executive function measured by the Clock Drawing Test (CDT), and functional disability measured by the Ability of Daily Living (ADL) scale at three and six months. RESULTS: : At three months, the acupuncture group had a greater decrease in mean ADAS-cog score (-2.33 ± 0.31) than the citicoline group (-1.38 ± 0.34) with a mean difference of -0.95 (95% CI, -1.84 to -0.07, P = 0.035). The mean change from baseline to six months in ADAS-cog also significantly favored acupuncture treatments (acupuncture change -2.61 vs citicoline -1.25, difference: -1.36 points; 95% CI, -2.20 to -0.51; P = 0.002). There was no difference between the two groups on CDT and ADL scores at either time point. CONCLUSION: : Compared with citicoline, acupuncture has comparable and even superior efficacy with improved cognitive and daily living performance as a complementary and alternative medicine treatment for VCIND.
Authors: Lu Wang; Jing-Wen Yang; Li-Ting Lin; Jin Huang; Xue-Rui Wang; Xin-Tong Su; Yan Cao; Marc Fisher; Cun-Zhi Liu Journal: Oxid Med Cell Longev Date: 2020-08-11 Impact factor: 6.543