Fenfei Wanggong1, Jianfeng Xiang2, Shichen Yang3, Weilan Zhang4, Reziya Tuerganbieke5. 1. Department of Neurology, Xinhua Hospital of Ily Kazakh Autonomous Prefecture Ily, Xinjiang Uygur Autonomous Region, China. 2. Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine Shanghai City, China. 3. Department of Neurology, The People's Hospital of Xinyuan County Ily, Xinjiang Uygur Autonomous Region, China. 4. General Medicine, Shanghai Fengxian District Central Hospital (South Campus, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University) Shanghai City, China. 5. Department of Neurology, The People's Hospital of Zhaosu County Ily, Xinjiang Uygur Autonomous Region, China.
Abstract
OBJECTIVE: To study the correlation of serum uric acid (UA), cystatin C (Cys-C) and high-sensitivity C-reactive protein (hs-CRP) with cognitive impairment in lacunar cerebral infarction. METHODS: Total 198 patients with lacunar cerebral infarction were selected and divided into 4 groups according to their cognitive function, with 65 cases in the normal group, 72 cases in the mild cognitive impairment group, 38 cases in the moderate cognitive impairment group and 23 cases in the severe cognitive impairment group. The hs-CRP, serum UA, Cys-C and Montreal Cognitive Assessment (MoCA) were measured upon admission. RESULTS: There were statistical differences in hs-CRP, UA and Cys-C among the four groups (all P<0.001). MoCA was negatively correlated with hs-CRP, UA and Cys-C (all P<0.001). Multivariate logistic regression analysis showed that elevated levels of hs-CRP, UA and Cys-C were the influencing factors of cognitive impairment in patients with lacunar cerebral infarction (all P<0.05). CONCLUSION: The levels of hs-CRP, UA and Cys-C in patients with lacunar cerebral infarction increase with the aggravation of cognitive impairment, and high hs-CRP, UA and Cys-C are independent risk factors of cognitive impairment in patients with lacunar cerebral infarction. AJTR
OBJECTIVE: To study the correlation of serum uric acid (UA), cystatin C (Cys-C) and high-sensitivity C-reactive protein (hs-CRP) with cognitive impairment in lacunar cerebral infarction. METHODS: Total 198 patients with lacunar cerebral infarction were selected and divided into 4 groups according to their cognitive function, with 65 cases in the normal group, 72 cases in the mild cognitive impairment group, 38 cases in the moderate cognitive impairment group and 23 cases in the severe cognitive impairment group. The hs-CRP, serum UA, Cys-C and Montreal Cognitive Assessment (MoCA) were measured upon admission. RESULTS: There were statistical differences in hs-CRP, UA and Cys-C among the four groups (all P<0.001). MoCA was negatively correlated with hs-CRP, UA and Cys-C (all P<0.001). Multivariate logistic regression analysis showed that elevated levels of hs-CRP, UA and Cys-C were the influencing factors of cognitive impairment in patients with lacunar cerebral infarction (all P<0.05). CONCLUSION: The levels of hs-CRP, UA and Cys-C in patients with lacunar cerebral infarction increase with the aggravation of cognitive impairment, and high hs-CRP, UA and Cys-C are independent risk factors of cognitive impairment in patients with lacunar cerebral infarction. AJTR
Authors: Kaavya Narasimhalu; Jasinda Lee; Yi Lin Leong; Lu Ma; Deidre A De Silva; Meng Cheong Wong; Hui Meng Chang; Christopher Chen Journal: Int J Stroke Date: 2013-03-12 Impact factor: 5.266