Fatih Alper Akcan1, Yusuf Dündar2, Hümeyra Bayram Akcan3, Ahmet Uluat4, Derya Cebeci5, İlhan Ünlü5. 1. Department of Otorhinolaryngology, Düzce University School of Medicine, Düzce, Turkey. f.akcan@yahoo.com. 2. Department of Otolaryngology-Head and Neck Surgery, Wayne State University, Detroit, MI, USA. 3. Department of Internal Medicine, Ministry of Health, Atatürk Hospital, Düzce, Turkey. 4. Department of Otolaryngology, Ministry of Health, Balıkesir Hospital, Balıkesir, Turkey. 5. Department of Otorhinolaryngology, Düzce University School of Medicine, Düzce, Turkey.
Abstract
OBJECTIVES: The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency. METHODS: A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency. RESULTS: The mean 25(HO)Vitamin-D levels were 14.32 ± 4.23 ng/mL (7-24.6) and 29.38 ± 7.05 ng/mL (25-53.8) in study and control groups, respectively (p < 0.001). The mean NMC time was 11.15 ± 3.05 (6.3-17.6) and 8.40 ± 2.33 (6-13.2) in study and control groups, respectively (p < 0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 ± 10.03 and the mean NMC time was 9.56 ± 2.54 (p < 0.001). CONCLUSION: The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.
OBJECTIVES: The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency. METHODS: A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency. RESULTS: The mean 25(HO)Vitamin-D levels were 14.32 ± 4.23 ng/mL (7-24.6) and 29.38 ± 7.05 ng/mL (25-53.8) in study and control groups, respectively (p < 0.001). The mean NMC time was 11.15 ± 3.05 (6.3-17.6) and 8.40 ± 2.33 (6-13.2) in study and control groups, respectively (p < 0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 ± 10.03 and the mean NMC time was 9.56 ± 2.54 (p < 0.001). CONCLUSION: The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.
Authors: J J Cannell; R Vieth; J C Umhau; M F Holick; W B Grant; S Madronich; C F Garland; E Giovannucci Journal: Epidemiol Infect Date: 2006-09-07 Impact factor: 2.451
Authors: Jessica R Levi; Robert M Brody; Katie McKee-Cole; Edmund Pribitkin; Robert O'Reilly Journal: Int J Pediatr Otorhinolaryngol Date: 2013-04-04 Impact factor: 1.675