Rebecca E Walker1, Jim Bartley2, Carlos A Camargo3, Edwin A Mitchell4. 1. Department of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. r.walker@auckland.ac.nz. 2. Division of Otolaryngology-Head and Neck Surgery, Counties-Manukau District Health Board, Auckland, New Zealand. 3. Department of Emergency Medicine and Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA. 4. Department of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Abstract
PURPOSE OF REVIEW: To examine the relationship between vitamin D and otitis media. RECENT FINDINGS: Vitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which are effective against otopathogens and biofilm formation, supporting a less inflammatory immune response, or promoting beneficial commensal bacteria. This review will explore risk factors of both otitis media and vitamin D deficiency, the evidence of vitamin D being beneficial for various forms of otitis media, and possible mechanisms of action.
PURPOSE OF REVIEW: To examine the relationship between vitamin D and otitis media. RECENT FINDINGS:Vitamin D deficiency has been associated with several respiratory diseases, including otitis media. Vitamin D supplementation may reduce the risk of otitis media. This relationship may be explained by vitamin D supporting the immune system by upregulating antimicrobial peptides which are effective against otopathogens and biofilm formation, supporting a less inflammatory immune response, or promoting beneficial commensal bacteria. This review will explore risk factors of both otitis media and vitamin D deficiency, the evidence of vitamin D being beneficial for various forms of otitis media, and possible mechanisms of action.
Authors: George A Gates; Jerome O Klein; David J Lim; Goro Mogi; Pearay L Ogra; Michael M Pararella; Jack L Paradise; Mirko Tos Journal: Ann Otol Rhinol Laryngol Suppl Date: 2002-03