Ender Sahin1, Mehmet Hamamcı2, Yunus Kantekin3. 1. Department of Otolaryngology, Faculty of Medicine, Bozok University, Atatürk Yolu 7. Km, 66100, Yozgat, Turkey. dr.endersahin@gmail.com. 2. Department of Neurology, Faculty of Medicine, Bozok University, Yozgat, Turkey. 3. Department of Otolaryngology, Faculty of Medicine, Bozok University, Atatürk Yolu 7. Km, 66100, Yozgat, Turkey.
Abstract
OBJECTIVES: The aim of the present study was to measure nasal mucociliary clearance (NMC) time in the patients with MS and to compare the findings with healthy population. METHODS: Totally 97 individuals including 47 patients with relapsing-remitting multiple sclerosis and 50 healthy volunteers were enrolled into the study. Saccharin clearance test was performed on both groups and NMC time was measured. Data analysis was performed by SPSS version 24.0 statistics program (SPSS Inc., Chicago, Illinois, USA). Statistical tests were interpreted at p < 0.05 significance level. RESULTS: The NMC time averages in MS patients and healthy control group were 12.43 ± 4.05 min and 8.14 ± 2.87 min, respectively; the difference between the groups was significant (p < 0.001). There was a statistically strong association between NMC time values and Expanded Disability Status Scale (EDSS) values in MS patients (r = 0.817, p < 0.001). CONCLUSION: We found nasal mucociliary transport time longer in MS patients than healthy population in the present study. To the best of our knowledge, there is not any study conducted about this topic in the literature. We believe that our findings would shed a light on further studies.
OBJECTIVES: The aim of the present study was to measure nasal mucociliary clearance (NMC) time in the patients with MS and to compare the findings with healthy population. METHODS: Totally 97 individuals including 47 patients with relapsing-remitting multiple sclerosis and 50 healthy volunteers were enrolled into the study. Saccharin clearance test was performed on both groups and NMC time was measured. Data analysis was performed by SPSS version 24.0 statistics program (SPSS Inc., Chicago, Illinois, USA). Statistical tests were interpreted at p < 0.05 significance level. RESULTS: The NMC time averages in MSpatients and healthy control group were 12.43 ± 4.05 min and 8.14 ± 2.87 min, respectively; the difference between the groups was significant (p < 0.001). There was a statistically strong association between NMC time values and Expanded Disability Status Scale (EDSS) values in MSpatients (r = 0.817, p < 0.001). CONCLUSION: We found nasal mucociliary transport time longer in MSpatients than healthy population in the present study. To the best of our knowledge, there is not any study conducted about this topic in the literature. We believe that our findings would shed a light on further studies.
Authors: Claudia Staffieri; Andrea Lovato; Federica Aielli; Martina Bortoletto; Luciano Giacomelli; Mariella Carrieri; Salvatore Romeo; Paolo Boscolo-Rizzo; Maria Cristina Da Mosto; Giovanni Battista Bartolucci; Gino Marioni; Maria Luisa Scapellato Journal: Int Forum Allergy Rhinol Date: 2015-06-05 Impact factor: 3.858