| Literature DB >> 30643258 |
Richard Karlsson Linnér1,2,3, Pietro Biroli4, Edward Kong5, S Fleur W Meddens6,7,8, Robbee Wedow9,10,11,12, Mark Alan Fontana13,14, Maël Lebreton15,16, Stephen P Tino17, Abdel Abdellaoui18, Anke R Hammerschlag6, Michel G Nivard18, Aysu Okbay6,8, Cornelius A Rietveld7,19,20, Pascal N Timshel21,22, Maciej Trzaskowski23, Ronald de Vlaming6,7,8, Christian L Zünd4, Yanchun Bao24, Laura Buzdugan25,4, Ann H Caplin26, Chia-Yen Chen9,11,27, Peter Eibich28,29,30, Pierre Fontanillas31, Juan R Gonzalez32,33,34, Peter K Joshi35, Ville Karhunen36, Aaron Kleinman31, Remy Z Levin37, Christina M Lill38, Gerardus A Meddens39, Gerard Muntané40,41,42, Sandra Sanchez-Roige43, Frank J van Rooij20, Erdogan Taskesen6, Yang Wu23, Futao Zhang23, Adam Auton31, Jason D Boardman44,45,46, David W Clark35, Andrew Conlin47, Conor C Dolan18, Urs Fischbacher48,49, Patrick J F Groenen7,50, Kathleen Mullan Harris51,52, Gregor Hasler53, Albert Hofman10,20, Mohammad A Ikram20, Sonia Jain54, Robert Karlsson55, Ronald C Kessler56, Maarten Kooyman57, James MacKillop58,59, Minna Männikkö36, Carlos Morcillo-Suarez40, Matthew B McQueen60, Klaus M Schmidt61, Melissa C Smart24, Matthias Sutter62,63,64, A Roy Thurik7,65, André G Uitterlinden66, Jon White67, Harriet de Wit68, Jian Yang23,69, Lars Bertram38,70,71, Dorret I Boomsma18, Tõnu Esko72, Ernst Fehr4, David A Hinds31, Magnus Johannesson73, Meena Kumari24, David Laibson5, Patrik K E Magnusson55, Michelle N Meyer74, Arcadi Navarro40,75,76, Abraham A Palmer43,77, Tune H Pers21,22, Danielle Posthuma6,78, Daniel Schunk79, Murray B Stein43,54, Rauli Svento47, Henning Tiemeier20, Paul R H J Timmers35, Patrick Turley9,11,80, Robert J Ursano81, Gert G Wagner29,82, James F Wilson35,83, Jacob Gratten23,84, James J Lee85, David Cesarini86, Daniel J Benjamin80,87,88, Philipp D Koellinger6,8,89, Jonathan P Beauchamp90.
Abstract
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.Entities:
Mesh：
Year: 2019 PMID： 30643258 PMCID： PMC6713272 DOI： 10.1038/s41588-018-0309-3
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330