Marwa Waheed1, Muhammad Bilal Hussain1, Ahsan Javed1, Zarina Mushtaq1, Sadia Hassan1, Mohammad Ali Shariati2, Muhammad Usman Khan3, Majid Majeed1, Manisha Nigam4, Abhay Prakash Mishra5, Mojtaba Heydari6. 1. Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan. 2. Laboratory of Biocontrol and Antimicrobial Resistance, Orel State University Named After I.S. Turgenev, 302026, Orel, Russia. 3. Bioproducts Sciences and Engineering Laboratory (BSEL), Washington State University, Richland, 99354, WA, USA; Department of Energy Systems Engineering, Faculty of Agricultural Engineering and Technology, University of Agriculture, 38000, Faisalabad, Pakistan. 4. Department of Biochemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal, Uttarakhand, India. 5. Department of Pharmaceutical Chemistry, H. N. B. Garhwal (A Central) University, Srinagar Garhwal, Uttarakhand, India. Electronic address: abhaypharmachemhnbgu@gmail.com. 6. Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mheydari@sums.ac.ir.
Abstract
BACKGROUND: Globally, cancer ranks among the most common causes of death. Multiple experimental and clinical studies have investigated anticancer effects of honey with promising results. This study focused on potential background mechanisms of this effect. METHODS: The current literature was reviewed for potential anticancer pathways which are suggested for honey and its ingredients. RESULTS: Flavonoids (kaempferol, catechin, and quercetin) and phenolic acids (caffeic acid and gallic acid) are the most important ingredients of honey with known anti-cancer activity. The main suggested mechanisms for anti-cancer activity of honey and its ingredients are antioxidant, apoptotic, tumor necrosis factor inhibiting, antiproliferative, immunomodulatory, anti-inflammatory and estrogenic effects. CONCLUSION: This review collates the current scientific understanding on the mechanism of anti-cancer activity of honey.
BACKGROUND: Globally, cancer ranks among the most common causes of death. Multiple experimental and clinical studies have investigated anticancer effects of honey with promising results. This study focused on potential background mechanisms of this effect. METHODS: The current literature was reviewed for potential anticancer pathways which are suggested for honey and its ingredients. RESULTS:Flavonoids (kaempferol, catechin, and quercetin) and phenolic acids (caffeic acid and gallic acid) are the most important ingredients of honey with known anti-cancer activity. The main suggested mechanisms for anti-cancer activity of honey and its ingredients are antioxidant, apoptotic, tumor necrosis factor inhibiting, antiproliferative, immunomodulatory, anti-inflammatory and estrogenic effects. CONCLUSION: This review collates the current scientific understanding on the mechanism of anti-cancer activity of honey.
Authors: Muhammad Faiz Zulkifli; Mohd Naim Fadhli Mohd Radzi; Jonel P Saludes; Doralyn S Dalisay; Wan Iryani Wan Ismail Journal: J Evid Based Integr Med Date: 2022 Jan-Dec
Authors: Mohammad A I Al-Hatamleh; Jennifer C Boer; Kirsty L Wilson; Magdalena Plebanski; Rohimah Mohamud; Mohd Zulkifli Mustafa Journal: Biomolecules Date: 2020-06-18
Authors: O Atolani; N Adamu; O S Oguntoye; M F Zubair; O A Fabiyi; R A Oyegoke; O S Adeyemi; E T Areh; D E Tarigha; L Kambizi; G A Olatunji Journal: Heliyon Date: 2020-02-13