Literature DB >> 30611668

Astrocyte Biomarkers in Alzheimer's Disease.

Stephen F Carter1, Karl Herholz1, Pedro Rosa-Neto2, Luc Pellerin3, Agneta Nordberg4, Eduardo R Zimmer5.   

Abstract

Astrocytic contributions to Alzheimer's disease (AD) progression were, until recently, largely overlooked. Astrocytes are integral to normal brain function and astrocyte reactivity is an early feature of AD, potentially providing a promising target for preclinical diagnosis and treatment. Several in vivo AD biomarkers already exist, but presently there is a paucity of specific and sensitive in vivo astrocyte biomarkers that can accurately measure preclinical AD. Measuring monoamine oxidase-B with neuroimaging and glial fibrillary acidic protein from bodily fluids are biomarkers that are currently available. Developing novel, more specific, and sensitive astrocyte biomarkers will make it possible to pharmaceutically target chemical pathways that preserve beneficial astrocytic functions in response to AD pathology. This review discusses astrocyte biomarkers in the context of AD.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; astrocytes; biomarkers; fluid; imaging

Year:  2019        PMID： 30611668     DOI： 10.1016/j.molmed.2018.11.006

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  64 in total

1.  Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography.

Authors:  Viktoria Zoufal; Severin Mairinger; Markus Krohn; Thomas Wanek; Thomas Filip; Michael Sauberer; Johann Stanek; Claudia Kuntner; Jens Pahnke; Oliver Langer
Journal:  J Cereb Blood Flow Metab       Date:  2019-06-13       Impact factor: 6.200

Review 2.  The basis of cellular and regional vulnerability in Alzheimer's disease.

Authors:  Dunja Mrdjen; Edward J Fox; Syed A Bukhari; Kathleen S Montine; Sean C Bendall; Thomas J Montine
Journal:  Acta Neuropathol       Date:  2019-08-07       Impact factor: 17.088

Review 3.  Neuropathological assessment of the Alzheimer spectrum.

Authors:  Kurt A Jellinger
Journal:  J Neural Transm (Vienna)       Date:  2020-08-01       Impact factor: 3.575

4.  Mulberry Fruit Extract Alleviates Cognitive Impairment by Promoting the Clearance of Amyloid-β and Inhibiting Neuroinflammation in Alzheimer's Disease Mice.

Authors:  Dianxun Liu; Dongqing Du
Journal:  Neurochem Res       Date:  2020-06-01       Impact factor: 3.996

5.  14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease.

Authors:  Wenjun Chen; Mengyao Wang; Minzhen Zhu; Wenchao Xiong; Xihe Qin; Xinhong Zhu
Journal:  J Neurosci       Date:  2020-09-24       Impact factor: 6.167

Review 6.  Astroglia in Alzheimer's Disease.

Authors:  Alexei Verkhratsky; Vladimir Parpura; Jose Julio Rodriguez-Arellano; Robert Zorec
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

7.  The proteasome regulator PI31 is required for protein homeostasis, synapse maintenance, and neuronal survival in mice.

Authors:  Adi Minis; Jose A Rodriguez; Avi Levin; Kai Liu; Eve-Ellen Govek; Mary E Hatten; Hermann Steller
Journal:  Proc Natl Acad Sci U S A       Date:  2019-11-21       Impact factor: 11.205

8.  Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.

Authors:  Claudia Salcedo; Antonie Wagner; Jens V Andersen; Kasper Tore Vinten; Helle S Waagepetersen; Arne Schousboe; Kristine K Freude; Blanca I Aldana
Journal:  Neurochem Res       Date:  2021-03-12       Impact factor: 3.996

Review 9.  Reactive astrocyte nomenclature, definitions, and future directions.

Authors:  András Lakatos; James P O'Callaghan; Gabor C Petzold; Alberto Serrano-Pozo; Christian Steinhäuser; Andrea Volterra; Giorgio Carmignoto; Carole Escartin; Elena Galea; Amit Agarwal; Nicola J Allen; Alfonso Araque; Luis Barbeito; Ari Barzilai; Dwight E Bergles; Gilles Bonvento; Arthur M Butt; Wei-Ting Chen; Martine Cohen-Salmon; Colm Cunningham; Benjamin Deneen; Bart De Strooper; Blanca Díaz-Castro; Cinthia Farina; Marc Freeman; Vittorio Gallo; James E Goldman; Steven A Goldman; Magdalena Götz; Antonia Gutiérrez; Philip G Haydon; Dieter H Heiland; Elly M Hol; Matthew G Holt; Masamitsu Iino; Ksenia V Kastanenka; Helmut Kettenmann; Baljit S Khakh; Schuichi Koizumi; C Justin Lee; Shane A Liddelow; Brian A MacVicar; Pierre Magistretti; Albee Messing; Anusha Mishra; Anna V Molofsky; Keith K Murai; Christopher M Norris; Seiji Okada; Stéphane H R Oliet; João F Oliveira; Aude Panatier; Vladimir Parpura; Marcela Pekna; Milos Pekny; Luc Pellerin; Gertrudis Perea; Beatriz G Pérez-Nievas; Frank W Pfrieger; Kira E Poskanzer; Francisco J Quintana; Richard M Ransohoff; Miriam Riquelme-Perez; Stefanie Robel; Christine R Rose; Jeffrey D Rothstein; Nathalie Rouach; David H Rowitch; Alexey Semyanov; Swetlana Sirko; Harald Sontheimer; Raymond A Swanson; Javier Vitorica; Ina-Beate Wanner; Levi B Wood; Jiaqian Wu; Binhai Zheng; Eduardo R Zimmer; Robert Zorec; Michael V Sofroniew; Alexei Verkhratsky
Journal:  Nat Neurosci       Date:  2021-02-15       Impact factor: 24.884

Review 10.  Molecular Imaging Approaches in Dementia.

Authors:  Victor L Villemagne; Frederik Barkhof; Valentina Garibotto; Susan M Landau; Agneta Nordberg; Bart N M van Berckel
Journal:  Radiology       Date:  2021-01-19       Impact factor: 11.105
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