Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Astroglia in Alzheimer's Disease.

Literature DB >> 31583592

Astroglia in Alzheimer's Disease.

Alexei Verkhratsky^1,2,3, Vladimir Parpura^4,5, Jose Julio Rodriguez-Arellano^6,7, Robert Zorec^8,9.

Abstract

Alzheimer's disease is the most common cause of dementia. Cellular changes in the brains of the patients suffering from Alzheimer's disease occur well in advance of the clinical symptoms. At the cellular level, the most dramatic is a demise of neurones. As astroglial cells carry out homeostatic functions of the brain, it is certain that these cells are at least in part a cause of Alzheimer's disease. Historically, Alois Alzheimer himself has recognised this at the dawn of the disease description. However, the role of astroglia in this disease has been understudied. In this chapter, we summarise the various aspects of glial contribution to this disease and outline the potential of using these cells in prevention (exercise and environmental enrichment) and intervention of this devastating disease.

Entities: Chemical Disease Gene Mutation Species

Keywords: Alzheimer’s disease; Astrocytes; Astroglial atrophy; Calcium signalling; Neurodegeneration; Pathological ageing; Stem cells

Mesh：

Year: 2019 PMID： 31583592 PMCID： PMC7266005 DOI： 10.1007/978-981-13-9913-8_11

Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622

332 in total

1. Microdomains for neuron-glia interaction: parallel fiber signaling to Bergmann glial cells.

Authors: J Grosche; V Matyash; T Möller; A Verkhratsky; A Reichenbach; H Kettenmann
Journal: Nat Neurosci Date: 1999-02 Impact factor: 24.884

2. Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains.

Authors: Robert G Nagele; Michael R D'Andrea; H Lee; Venkateswar Venkataraman; Hoau-Yan Wang
Journal: Brain Res Date: 2003-05-09 Impact factor: 3.252

Review 3. Astroglial cradle in the life of the synapse.

Authors: Alexei Verkhratsky; Maiken Nedergaard
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2014-10-19 Impact factor: 6.237

4. The relationship between quantitative measures of dementia and of degenerative changes in the cerebral grey matter of elderly subjects.

Authors: M Roth; B E Tomlinson; G Blessed
Journal: Proc R Soc Med Date: 1967-03

5. Astrocytic face of Alzheimer's disease.

Authors: Robert Zorec; Vladimir Parpura; Nina Vardjan; Alexej Verkhratsky
Journal: Behav Brain Res Date: 2016-05-09 Impact factor: 3.332

6. Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.

Authors: J C Dodart; C Mathis; J Saura; K R Bales; S M Paul; A Ungerer
Journal: Neurobiol Dis Date: 2000-04 Impact factor: 5.996

7. Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments.

Authors: T Ishihara; M Higuchi; B Zhang; Y Yoshiyama; M Hong; J Q Trojanowski; V M Lee
Journal: J Neurosci Date: 2001-08-15 Impact factor: 6.167

8. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

Authors: C Janus; J Pearson; J McLaurin; P M Mathews; Y Jiang; S D Schmidt; M A Chishti; P Horne; D Heslin; J French; H T Mount; R A Nixon; M Mercken; C Bergeron; P E Fraser; P St George-Hyslop; D Westaway
Journal: Nature Date: 2000 Dec 21-28 Impact factor: 49.962

9. Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.

Authors: C Garwood; A Faizullabhoy; S B Wharton; P G Ince; P R Heath; P J Shaw; L Baxter; C Gelsthorpe; G Forster; F E Matthews; C Brayne; J E Simpson
Journal: Neuropathol Appl Neurobiol Date: 2013-12 Impact factor: 8.090

10. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain.

Authors: Gary W Arendash; Jada Lewis; Ralph E Leighty; Eileen McGowan; Jennifer R Cracchiolo; Mike Hutton; Marcos F Garcia
Journal: Brain Res Date: 2004-06-25 Impact factor: 3.252

19 in total

Review 1. Astrocytes in depression and Alzheimer's disease.

Authors: Yang Liao; Qu Xing; Qianqian Li; Jing Zhang; Ruiyuan Pan; Zengqiang Yuan
Journal: Front Med Date: 2021-11-23 Impact factor: 4.592

Review 2. A putative role for lncRNAs in epigenetic regulation of memory.

Authors: Ashleigh B Irwin; Rudhab Bahabry; Farah D Lubin
Journal: Neurochem Int Date: 2021-09-14 Impact factor: 3.921

Review 3. TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications.

Authors: Jian Luo
Journal: Biomedicines Date: 2022-05-23

4. Overdosing on iron: Elevated iron and degenerative brain disorders.

Authors: Santosh R D'Mello; Mark C Kindy
Journal: Exp Biol Med (Maywood) Date: 2020-09-02

Review 5. Roles of astrocytes in response to aging, Alzheimer's disease and multiple sclerosis.

Authors: Talia M Planas-Fontánez; Danielle M Sainato; Isha Sharma; Cheryl F Dreyfus
Journal: Brain Res Date: 2021-04-01 Impact factor: 3.610

Review 6. Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit.

Authors: Shinichi Takahashi
Journal: Neuropathology Date: 2020-02-09 Impact factor: 1.906