Literature DB >> 30604167

Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice.

Dan Luo1,2, Zhengyun Zuo3, Hongyan Zhao4, Yong Tan5, Cheng Xiao6.   

Abstract

Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of Tand B cells; ratio of Tcell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.

Entities:  

Keywords:  Tripterygium wilfordii Hook F; clinical studies; immunoregulation

Mesh：

Substances：

Year:  2019        PMID： 30604167     DOI： 10.1007/s11684-018-0649-5

Source DB:  PubMed          Journal:  Front Med        ISSN： 2095-0217            Impact factor:   4.592


  39 in total

Review 1.  Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

Authors:  Anita M Brinker; Jun Ma; Peter E Lipsky; Ilya Raskin
Journal:  Phytochemistry       Date:  2007-01-23       Impact factor: 4.072

2.  Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway.

Authors:  Yanlong Yang; Yujin Ye; Qian Qiu; Youjun Xiao; Mingcheng Huang; Maohua Shi; Liuqin Liang; Xiuyan Yang; Hanshi Xu
Journal:  Int Immunopharmacol       Date:  2016-10-27       Impact factor: 4.932

3.  [Clinical effect of Tripterygiitotorum combined with prednisone and its effect on serum IL-6 level in treating patients with myasthenia gravis].

Authors:  Zuo-xiao Li; Hua Tan; Xian-ji Xiong
Journal:  Zhongguo Zhong Xi Yi Jie He Za Zhi       Date:  2002-03

4.  [Effect of Tripterygium wilfordii polyglycoside on serum IL-2 and TNF-alpha in patients with acute anterior U-veitis].

Authors:  Qing-shan Huang; Zhao-lai Zhang; Yu-ming Liu
Journal:  Zhongguo Zhong Xi Yi Jie He Za Zhi       Date:  2002-06

5.  [Effect of Tripterygium wilfordii on Th1, Th2 cytokines production in asthma patients].

Authors:  K X Lin; C Z Wang; G S Qian
Journal:  Zhongguo Zhong Xi Yi Jie He Za Zhi       Date:  2001-01

6.  Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial.

Authors:  Raphaela Goldbach-Mansky; Mildred Wilson; Roy Fleischmann; Nancy Olsen; Joel Silverfield; Phillip Kempf; Alan Kivitz; Yvonne Sherrer; Frank Pucino; Gyorgy Csako; Rene Costello; Tuyet Hang Pham; Christopher Snyder; Désirée van der Heijde; Xuelian Tao; Robert Wesley; Peter E Lipsky
Journal:  Ann Intern Med       Date:  2009-08-18       Impact factor: 25.391

7.  [Peripheral blood cell factors of Graves ophthalmopathy and effect of intervention with tripterygium glycosides].

Authors:  Jian-Ping Xu; Jian-Ping Xu; Chen Xu; Jun Chen; Zhi-Hua Jin; Hong-Fei Zheng; Jun Zhu
Journal:  Zhongguo Zhong Yao Za Zhi       Date:  2014-02

8.  Effects of Tripterygium wilfordii glycosides on regulatory T cells and Th17 in an IgA nephropathy rat model.

Authors:  F Chen; Y L Ma; H Ding; B P Chen
Journal:  Genet Mol Res       Date:  2015-11-23

9.  Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy.

Authors:  Jie Shen; Zhangfang Li; Wenting Li; Ying Ge; Min Xie; Meng Lv; Yanfei Fan; Zhi Chen; Defu Zhao; Yajuan Han
Journal:  Dis Markers       Date:  2015-05-18       Impact factor: 3.434

10.  Corrigendum: Safety Profiles of Tripterygium wilfordii Hook F: A Systematic Review and Meta-Analysis.

Authors:  Chi Zhang; Ping-Ping Sun; Hong-Tao Guo; Yan Liu; Jian Li; Xiao-Juan He; Ai-Ping Lu
Journal:  Front Pharmacol       Date:  2017-02-15       Impact factor: 5.810
View more
  12 in total

1.  Efficacy and Safety of Tripterygium Wilfordii Glycoside Tablets Combined with Acitretin Capsules in the Treatment of Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

Authors:  Qinghui Fu; Yunjie Zhu; Yiqi Fang; Changbo Dai
Journal:  Appl Bionics Biomech       Date:  2022-07-09       Impact factor: 1.664

2.  Tripterygium wilfordii Polyglycoside Ameliorated TNBS-Induced Colitis in Rats via Regulating Th17/Treg Balance in Intestinal Mucosa.

Authors:  Cui Zhang; Jingyi Ju; Xiaohan Wu; Jiaolan Yang; Qinglu Yang; Changqin Liu; Liang Chen; Xiaomin Sun
Journal:  J Inflamm Res       Date:  2021-04-01

3.  Mechanism of action of Tripterygium wilfordii for treatment of idiopathic membranous nephropathy based on network pharmacology.

Authors:  Honghong Shi; Yanjuan Hou; Xiaole Su; Jun Qiao; Qian Wang; Xiaojiao Guo; Zhihong Gao; Lihua Wang
Journal:  Ren Fail       Date:  2022-12       Impact factor: 2.606

Review 4.  Recent Advances in Traditional Chinese Medicine for Treatment of Podocyte Injury.

Authors:  Tianwen Yao; Wenxiang Su; Shisheng Han; Yan Lu; Yanqiu Xu; Min Chen; Yi Wang
Journal:  Front Pharmacol       Date:  2022-02-25       Impact factor: 5.810

5.  Tripterygium wilfordii Hook. f. Preparations for Rheumatoid Arthritis: An Overview of Systematic Reviews.

Authors:  Huimin Li; Ruixue Hu; Simin Xu; Zeqi Dai; Xue Wu; Jing Hu; Xing Liao
Journal:  Evid Based Complement Alternat Med       Date:  2022-04-12       Impact factor: 2.650

6.  Comprehensive Evaluation of the Quality of Tripterygium Glycosides Tablets Based on Multi-Component Quantification Combined with an In Vitro Biological Assay.

Authors:  Yadan Wang; Zhong Dai; Jiangong Yan; Xianfu Wu; Shuangcheng Ma
Journal:  Molecules       Date:  2022-08-10       Impact factor: 4.927

7.  Efficacy and Safety of Tripterygium Wilfordii Hook. F for Connective Tissue Disease-Associated Interstitial Lung Disease:A Systematic Review and Meta-Analysis.

Authors:  Yehui Li; Wen Zhu; Hailang He; Yordan Angelov Garov; Le Bai; Li Zhang; Jing Wang; Jinghai Wang; Xianmei Zhou
Journal:  Front Pharmacol       Date:  2021-06-10       Impact factor: 5.810

8.  Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.

Authors:  Juan Wang; Zhi-Qian Zhang; Fang-Qiong Li; Jia-Ning Chen; Xiaoting Gong; Bei-Bei Cao; Wei Wang
Journal:  Oncol Rep       Date:  2020-03-30       Impact factor: 3.906

9.  Adverse Events Associated With Treatment of Tripterygium wilfordii Hook F: A Quantitative Evidence Synthesis.

Authors:  Yi Ru; Ying Luo; Yaqiong Zhou; Le Kuai; Xiaoying Sun; Meng Xing; Liu Liu; Yi Lu; Seokgyeong Hong; Xi Chen; Jiankun Song; Yue Luo; Xiaoya Fei; Bin Li; Xin Li
Journal:  Front Pharmacol       Date:  2019-11-06       Impact factor: 5.810

10.  Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis.

Authors:  Caiwei Yu; Hui Liu; Chunjing Guo; Qiang Chen; Yanguo Su; Huimin Guo; Xiaoya Hou; Feng Zhao; Huaying Fan; Hui Xu; Yan Zhao; Xiaofeng Mu; Guohua Wang; Haiyu Xu; Daquan Chen
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.419
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.