Qinghui Fu1, Yunjie Zhu2, Yiqi Fang3, Changbo Dai4. 1. Department of Dermatology, Zunyi Hospital of Traditional Chinese Medicine, No. 8, Fenghuang South Road, Honghuagang District, Zunyi City, Guizhou 563099, China. 2. Department of Nephrology, Suzhou Hospital of Traditional Chinese Medicine, No. 18, Yangsu Road, Canglang New Town, No. 889, Wuzhong West Road, Suzhou, Jiangsu 215009, China. 3. Department of Hematology, Suzhou Hospital of Traditional Chinese Medicine, No. 18, Yangsu Road, Canglang New Town, No. 889, Wuzhong West Road, Suzhou, Jiangsu 215009, China. 4. Department of Dermatology, Suzhou TCM Hospital Affiliated to NanJing University of Chinese Medicine, No. 18, Yangsu Road, Canglang New Town, No. 889, Wuzhong West Road, Suzhou, Jiangsu 215009, China.
Abstract
Objective: To probe into the clinical efficacy of tripterygium wilfordii glycoside (TWGs) tablets combined with acitretin capsules in the treatment of patients with moderate to severe plaque psoriasis (MSPP). Methods: Thirty-six patients with MSPP were collected and divided into three groups, namely, group A (n = 12, TWG tablets + acitretin capsules), group B (n = 12, compound glycyrrhizin capsules + acitretin capsules), and group C (n = 12, acitretin capsules). The general data of the patients was recorded. In addition, a comparison was made before treatment, 4 weeks and 8 weeks after treatment in terms of the clinical efficacy, liver function indicators (alanine aminotransferase (ALT), aspartate transaminase (AST), and creatinine), psoriasis area, and severity index (PASI) scores. The incidence of adverse reactions after treatment and the recurrence rate during two months of follow-up was statistically analyzed. Results: The therapeutic effect of group A was superior to the other two groups, with obviously more satisfactory results of serum parameters, clinical efficacy and PASI score, and incidence of adverse reactions. Conclusions: TWGs combined with acitretin had better therapeutic effects and higher safety in the treatment of MSPP.
Objective: To probe into the clinical efficacy of tripterygium wilfordii glycoside (TWGs) tablets combined with acitretin capsules in the treatment of patients with moderate to severe plaque psoriasis (MSPP). Methods: Thirty-six patients with MSPP were collected and divided into three groups, namely, group A (n = 12, TWG tablets + acitretin capsules), group B (n = 12, compound glycyrrhizin capsules + acitretin capsules), and group C (n = 12, acitretin capsules). The general data of the patients was recorded. In addition, a comparison was made before treatment, 4 weeks and 8 weeks after treatment in terms of the clinical efficacy, liver function indicators (alanine aminotransferase (ALT), aspartate transaminase (AST), and creatinine), psoriasis area, and severity index (PASI) scores. The incidence of adverse reactions after treatment and the recurrence rate during two months of follow-up was statistically analyzed. Results: The therapeutic effect of group A was superior to the other two groups, with obviously more satisfactory results of serum parameters, clinical efficacy and PASI score, and incidence of adverse reactions. Conclusions: TWGs combined with acitretin had better therapeutic effects and higher safety in the treatment of MSPP.
Authors: Jasvinder A Singh; Gordon Guyatt; Alexis Ogdie; Dafna D Gladman; Chad Deal; Atul Deodhar; Maureen Dubreuil; Jonathan Dunham; M Elaine Husni; Sarah Kenny; Jennifer Kwan-Morley; Janice Lin; Paula Marchetta; Philip J Mease; Joseph F Merola; Julie Miner; Christopher T Ritchlin; Bernadette Siaton; Benjamin J Smith; Abby S Van Voorhees; Anna Helena Jonsson; Amit Aakash Shah; Nancy Sullivan; Marat Turgunbaev; Laura C Coates; Alice Gottlieb; Marina Magrey; W Benjamin Nowell; Ana-Maria Orbai; Soumya M Reddy; Jose U Scher; Evan Siegel; Michael Siegel; Jessica A Walsh; Amy S Turner; James Reston Journal: Arthritis Rheumatol Date: 2018-11-30 Impact factor: 10.995
Authors: Rosa Parisi; Deborah P M Symmons; Christopher E M Griffiths; Darren M Ashcroft Journal: J Invest Dermatol Date: 2012-09-27 Impact factor: 8.551