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Literature DB >> 30602760

Non-redundant functions of EMT transcription factors.

Marc P Stemmler¹, Rebecca L Eccles¹, Simone Brabletz¹, Thomas Brabletz².

Abstract

Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.

Entities: Chemical

Mesh：

Substances：
Transcription Factors

Year: 2019 PMID： 30602760 DOI： 10.1038/s41556-018-0196-y

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

159 in total

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Review 10. Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer.

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141 in total

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