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Literature DB >> 28945230

Cell plasticity in epithelial homeostasis and tumorigenesis.

Abstract

The adult organism is characterized by remarkable plasticity, which enables efficient regeneration and restoration of homeostasis after damage. When aberrantly activated, this plasticity contributes to tumour initiation and progression. Here we review recent advances in this field with a focus on cell fate changes and the epithelial-mesenchymal transition-two distinct, yet closely related, forms of plasticity with fundamental roles in homeostasis and cancer.

Entities: Disease

Mesh：

Year: 2017 PMID： 28945230 DOI： 10.1038/ncb3611

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Cited

82 in total

1. Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers.

Authors: Ian MacFawn; Hannah Wilson; Luke A Selth; Ian Leighton; Ilya Serebriiskii; R Christopher Bleackley; Osama Elzamzamy; Joshua Farris; Phillip M Pifer; Jennifer Richer; Steven M Frisch
Journal: Mol Immunol Date: 2018-11-30 Impact factor: 4.407

2. Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming.

Authors: Xian-Yang Qin; Naoshi Dohmae; Soichi Kojima
Journal: Proc Natl Acad Sci U S A Date: 2018-06-25 Impact factor: 11.205

Review 3. Metastatic niche functions and therapeutic opportunities.

Authors: Toni Celià-Terrassa; Yibin Kang
Journal: Nat Cell Biol Date: 2018-07-26 Impact factor: 28.824

4. Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?

Authors: Jason C Mills; Ben Z Stanger; Maike Sander
Journal: EMBO J Date: 2019-09-02 Impact factor: 11.598

Review 5. The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies.

Authors: Joaquín Araos; Jonathan P Sleeman; Boyan K Garvalov
Journal: Clin Exp Metastasis Date: 2018-08-31 Impact factor: 5.150

Cell plasticity in epithelial homeostasis and tumorigenesis.

1. Grainyhead-like-2 confers NK-sensitivity through interactions with epigenetic modifiers.

2. Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming.

Review 3. Metastatic niche functions and therapeutic opportunities.

4. Nomenclature for cellular plasticity: are the terms as plastic as the cells themselves?

Review 5. The role of hypoxic signalling in metastasis: towards translating knowledge of basic biology into novel anti-tumour strategies.

Review 6. Inflammation and Cancer: Triggers, Mechanisms, and Consequences.

Review 7. Emerging role of tumor cell plasticity in modifying therapeutic response.

Review 8. Investigating epithelial-to-mesenchymal transition with integrated computational and experimental approaches.

Review 9. Non-redundant functions of EMT transcription factors.

Review 10. Mesenchymal-epithelial transition in development and reprogramming.