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Literature DB >> 32348738

Tumor Plasticity and Resistance to Immunotherapy.

Lucas A Horn¹, Kristen Fousek¹, Claudia Palena².

Abstract

Tumor cell plasticity exhibited as an epithelial-mesenchymal transition (EMT) has been identified as a major obstacle for the effective treatment of many cancers. This process, which involves the dedifferentiation of epithelial tumor cells towards a motile, metastatic, and mesenchymal tumor phenotype, mediates resistance to conventional therapies and small-molecule targeted therapies. In this review, we highlight current research correlating the role of tumor plasticity with resistance to current immunotherapy approaches and discuss future and ongoing combination immunotherapy strategies to reduce tumor cell plasticity-driven resistance in cancer. Published by Elsevier Inc.

Entities: Chemical Disease Gene Species

Keywords: EMT; IL-8; TGF-β; immunotherapy resistance; tumor plasticity

Mesh：

Substances：

Year: 2020 PMID： 32348738 PMCID： PMC7192950 DOI： 10.1016/j.trecan.2020.02.001

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

83 in total

1. Novel transforming growth factor beta receptor I kinase inhibitor galunisertib (LY2157299) in advanced hepatocellular carcinoma.

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Journal: Liver Int Date: 2019-06-03 Impact factor: 5.828

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Journal: JCI Insight Date: 2019-04-04

4. AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity.

Authors: Stéphane Terry; Abderemane Abdou; Agnete S T Engelsen; Stéphanie Buart; Philippe Dessen; Stéphanie Corgnac; Davi Collares; Guillaume Meurice; Gro Gausdal; Véronique Baud; Pierre Saintigny; James B Lorens; Jean-Paul Thiery; Fathia Mami-Chouaib; Salem Chouaib
Journal: Cancer Immunol Res Date: 2019-09-05 Impact factor: 11.151

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Authors: Romaine I Fernando; Marianne D Castillo; Mary Litzinger; Duane H Hamilton; Claudia Palena
Journal: Cancer Res Date: 2011-06-08 Impact factor: 12.701

Review 6. Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?

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Journal: Am Soc Clin Oncol Educ Book Date: 2019-05-17

Review 7. Cellular Plasticity in Cancer.

Authors: Salina Yuan; Robert J Norgard; Ben Z Stanger
Journal: Cancer Discov Date: 2019-04-16 Impact factor: 39.397

8. Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2.

Authors: Dean Y Maeda; Angela M Peck; Aaron D Schuler; Mark T Quinn; Liliya N Kirpotina; Winston N Wicomb; Guo-Huang Fan; John A Zebala
Journal: J Med Chem Date: 2014-10-08 Impact factor: 7.446

9. TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

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Journal: Nature Date: 2018-02-14 Impact factor: 49.962

10. The consensus molecular subtypes of colorectal cancer.

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Journal: Nat Med Date: 2015-10-12 Impact factor: 53.440

37 in total

1. Retinoic Acid-Inducible Gene I-Like Receptors Activate Snail To Limit RNA Viral Infections.

Authors: Dhiviya Vedagiri; Divya Gupta; Anurag Mishra; Gayathri Krishna; Meenakshi Bhaskar; Vishal Sah; Anirban Basu; Debasis Nayak; Manjula Kalia; Mohanan Valiya Veettil; Krishnan Harinivas Harshan
Journal: J Virol Date: 2021-08-11 Impact factor: 5.103

2. A FBXO7/EYA2-SCF^FBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells.

Authors: Jia Z Shen; Zhixin Qiu; Qiulian Wu; Guoxin Zhang; Rebecca Harris; Dahui Sun; Juha Rantala; William D Barshop; Linjie Zhao; Deguan Lv; Kwang-Ai Won; James Wohlschlegel; Olle Sangfelt; Heike Laman; Jeremy N Rich; Charles Spruck
Journal: Mol Cell Date: 2022-02-18 Impact factor: 17.970

Review 3. Cellular and molecular mechanisms of plasticity in cancer.

Authors: Stefan R Torborg; Zhuxuan Li; Jason E Chan; Tuomas Tammela
Journal: Trends Cancer Date: 2022-05-23

4. Immune Cell Networks Uncover Candidate Biomarkers of Melanoma Immunotherapy Response.

Authors: Duong H T Vo; Gerard McGleave; Ian M Overton
Journal: J Pers Med Date: 2022-06-11

Review 5. Emerging role of tumor cell plasticity in modifying therapeutic response.

Authors: Siyuan Qin; Jingwen Jiang; Yi Lu; Edouard C Nice; Canhua Huang; Jian Zhang; Weifeng He
Journal: Signal Transduct Target Ther Date: 2020-10-07

6. Emergence of a High-Plasticity Cell State during Lung Cancer Evolution.

Authors: Nemanja Despot Marjanovic; Matan Hofree; Jason E Chan; David Canner; Katherine Wu; Marianna Trakala; Griffin G Hartmann; Olivia C Smith; Jonathan Y Kim; Kelly Victoria Evans; Anna Hudson; Orr Ashenberg; Caroline B M Porter; Alborz Bejnood; Ayshwarya Subramanian; Kenneth Pitter; Yan Yan; Toni Delorey; Devan R Phillips; Nisargbhai Shah; Ojasvi Chaudhary; Alexander Tsankov; Travis Hollmann; Natasha Rekhtman; Pierre P Massion; John T Poirier; Linas Mazutis; Ruifang Li; Joo-Hyeon Lee; Angelika Amon; Charles M Rudin; Tyler Jacks; Aviv Regev; Tuomas Tammela
Journal: Cancer Cell Date: 2020-07-23 Impact factor: 31.743