Literature DB >> 3057629

Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.

A J Bitonti1, A Sjoerdsma, P P McCann, D E Kyle, A M Oduola, R N Rossan, W K Milhous, D E Davidson.   

Abstract

Desipramine and several other tricyclic antidepressant drugs reverse chloroquine resistance in Plasmodium falciparum in vitro at concentrations observed in the plasma of human patients treated for depression. Reversal of resistance is associated with increased chloroquine accumulation in the parasite, probably because of inhibition of a putative chloroquine efflux pump. When owl monkeys (Aotus lemurinus lemurinus) infected with chloroquine-resistant Plasmodium falciparum were treated with chloroquine plus desipramine, their parasitemias were rapidly suppressed. Desipramine was found to be one of the most effective compounds yet described for the reversal of chloroquine resistance both in vitro and in vivo.

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Year:  1988        PMID： 3057629     DOI： 10.1126/science.3057629

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  47 in total

1.  Structural analysis of chloroquine resistance reversal by imipramine analogs.

Authors:  A K Bhattacharjee; D E Kyle; J L Vennerstrom
Journal:  Antimicrob Agents Chemother       Date:  2001-09       Impact factor: 5.191

2.  Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Authors:  D A Fidock; T Nomura; A K Talley; R A Cooper; S M Dzekunov; M T Ferdig; L M Ursos; A B Sidhu; B Naudé; K W Deitsch; X Z Su; J C Wootton; P D Roepe; T E Wellems
Journal:  Mol Cell       Date:  2000-10       Impact factor: 17.970

3.  Potent synergistic in vitro interaction between nonantimicrobial membrane-active compounds and itraconazole against clinical isolates of Aspergillus fumigatus resistant to itraconazole.

Authors:  Javier Afeltra; Roxana G Vitale; Johan W Mouton; Paul E Verweij
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

4.  In vitro activities of chloroquine in combination with chlorpromazine or prochlorperazine against isolates of Plasmodium falciparum.

Authors:  L K Basco; J Le Bras
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

Review 5.  Molecular mechanisms of drug resistance.

Authors:  J D Hayes; C R Wolf
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

6.  Role of the neurotransmitter reuptake-blocking activity of antidepressants in reversing chloroquine resistance in vitro in Plasmodium falciparum.

Authors:  D Taylor; J C Walden; A H Robins; P J Smith
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

Review 7.  Status of antimalarial drugs under development.

Authors:  P L Olliaro; P I Trigg
Journal:  Bull World Health Organ       Date:  1995       Impact factor: 9.408

8.  Reversal of chloroquine resistance in Plasmodium falciparum using combinations of chemosensitizers.

Authors:  D A van Schalkwyk; J C Walden; P J Smith
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

9.  Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors.

Authors:  A M Ndifor; R E Howells; P G Bray; J L Ngu; S A Ward
Journal:  Antimicrob Agents Chemother       Date:  1993-06       Impact factor: 5.191

10.  Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene.

Authors:  D M Henderson; C D Sifri; M Rodgers; D F Wirth; N Hendrickson; B Ullman
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272
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