Literature DB >> 11502547

Structural analysis of chloroquine resistance reversal by imipramine analogs.

A K Bhattacharjee1, D E Kyle, J L Vennerstrom.   

Abstract

For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.

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Year:  2001        PMID： 11502547      PMCID： PMC90710          DOI： 10.1128/AAC.45.9.2655-2657.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Reversal of chloroquine resistance of 'wild' isolates of Plasmodium falciparum by desipramine.

Authors:  G Carosi; S Caligaris; G Fadat; F Castelli; A Matteelli; D Kouka-Bemba; G Roscigno
Journal:  Trans R Soc Trop Med Hyg       Date:  1991 Nov-Dec       Impact factor: 2.184

2.  Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum.

Authors:  A Salama; C A Facer
Journal:  Lancet       Date:  1990-01-20       Impact factor: 79.321

3.  Role of the neurotransmitter reuptake-blocking activity of antidepressants in reversing chloroquine resistance in vitro in Plasmodium falciparum.

Authors:  D Taylor; J C Walden; A H Robins; P J Smith
Journal:  Antimicrob Agents Chemother       Date:  2000-10       Impact factor: 5.191

4.  Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine.

Authors:  C M Menezes; K Kirchgatter; S M Di Santi; C Savalli; F G Monteiro; G A Paula; E I Ferreira
Journal:  Trans R Soc Trop Med Hyg       Date:  1997 Nov-Dec       Impact factor: 2.184

5.  Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum.

Authors:  W Peters; R Ekong; B L Robinson; D C Warhurst; X Q Pan
Journal:  Lancet       Date:  1989-08-05       Impact factor: 79.321

6.  Antimalarial properties of imipramine and amitriptyline.

Authors:  P Dutta; J Pinto; R Rivlin
Journal:  J Protozool       Date:  1990 Jan-Feb

7.  Chloroquine-potentiating action of antihistaminics in Plasmodium falciparum in vitro.

Authors:  L K Basco; P Ringwald; J Le Bras
Journal:  Ann Trop Med Parasitol       Date:  1991-04

8.  Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.

Authors:  A J Bitonti; A Sjoerdsma; P P McCann; D E Kyle; A M Oduola; R N Rossan; W K Milhous; D E Davidson
Journal:  Science       Date:  1988-12-02       Impact factor: 47.728

9.  Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children.

Authors:  A Sowunmi; A M Oduola; O A Ogundahunsi; C O Falade; G O Gbotosho; L A Salako
Journal:  Trans R Soc Trop Med Hyg       Date:  1997 Jan-Feb       Impact factor: 2.184

10.  Lack of effect of desipramine on the response to chloroquine of patients with chloroquine-resistant falciparum malaria.

Authors:  M Warsame; W H Wernsdorfer; A Björkman
Journal:  Trans R Soc Trop Med Hyg       Date:  1992 May-Jun       Impact factor: 2.184
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  10 in total

Review 1.  Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.

Authors:  Robert L Summers; Megan N Nash; Rowena E Martin
Journal:  Cell Mol Life Sci       Date:  2012-06       Impact factor: 9.261

2.  A chloroquine-like molecule designed to reverse resistance in Plasmodium falciparum.

Authors:  Steven J Burgess; Audrey Selzer; Jane Xu Kelly; Martin J Smilkstein; Michael K Riscoe; David H Peyton
Journal:  J Med Chem       Date:  2006-09-07       Impact factor: 7.446

3.  Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross.

Authors:  Jigar J Patel; Drew Thacker; John C Tan; Perri Pleeter; Lisa Checkley; Joseph M Gonzales; Bingbing Deng; Paul D Roepe; Roland A Cooper; Michael T Ferdig
Journal:  Mol Microbiol       Date:  2010-09-29       Impact factor: 3.501

Review 4.  Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions.

Authors:  Philippe Rasoanaivo; Colin W Wright; Merlin L Willcox; Ben Gilbert
Journal:  Malar J       Date:  2011-03-15       Impact factor: 2.979

5.  Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin.

Authors:  Vincent Delespaux; Hervé Sèna Vitouley; Tanguy Marcotty; Niko Speybroeck; Dirk Berkvens; Krisna Roy; Stanny Geerts; Peter Van den Bossche
Journal:  PLoS Negl Trop Dis       Date:  2010-09-28

6.  Discovery of dual function acridones as a new antimalarial chemotype.

Authors:  Jane X Kelly; Martin J Smilkstein; Reto Brun; Sergio Wittlin; Roland A Cooper; Kristin D Lane; Aaron Janowsky; Robert A Johnson; Rozalia A Dodean; Rolf Winter; David J Hinrichs; Michael K Riscoe
Journal:  Nature       Date:  2009-04-08       Impact factor: 49.962

7.  5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel.

Authors:  Christopher P Locher; Peter C Ruben; Jiri Gut; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

8.  Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

Authors:  Jane X Kelly; Martin J Smilkstein; Roland A Cooper; Kristin D Lane; Robert A Johnson; Aaron Janowsky; Rozalia A Dodean; David J Hinrichs; Rolf Winter; Michael Riscoe
Journal:  Antimicrob Agents Chemother       Date:  2007-09-10       Impact factor: 5.191

Review 9.  Reversed chloroquine molecules as a strategy to overcome resistance in malaria.

Authors:  David H Peyton
Journal:  Curr Top Med Chem       Date:  2012       Impact factor: 3.295

10.  Classical QSAR and Docking Simulation of 4-Pyridone Derivatives for Their Antimalarial Activity.

Authors:  Máryury Flores-Sumoza; Jackson J Alcázar; Edgar Márquez; José R Mora; Jesús Lezama; Esneyder Puello
Journal:  Molecules       Date:  2018-12-01       Impact factor: 4.411
  10 in total

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