Literature DB >> 3056824

What naevus is dysplastic, a syndrome and the commonest precursor of malignant melanoma? A riddle and an answer.

A B Ackerman1.   

Abstract

This assay examines critically the concept of 'dysplasia' as it applies to melanocytic neoplasia and concludes that the concept is flawed. Doubt is cast also upon the validity of the concepts of a dysplastic naevus and a dysplastic naevus syndrome. The author is of the view that most malignant melanomas arise de novo and not in pre-existing dysplastic naevi. Because so-called dysplastic naevi are considered by the author to be the commonest melanocytic naevi in man and devoid of nuclear atypia, he proposes that they be re-named 'common naevi' in the interest of simplicity, accuracy, and care of patients. Lastly, it is suggested that resolution of problems in the sphere of melanocytic neoplasia might be accomplished more readily were terms like dysplasia, dysplastic cells, dysplastic naevi, and the dysplastic naevus syndrome eschewed.

Entities:  

Mesh:

Year:  1988        PMID: 3056824     DOI: 10.1111/j.1365-2559.1988.tb02036.x

Source DB:  PubMed          Journal:  Histopathology        ISSN: 0309-0167            Impact factor:   5.087


  19 in total

Review 1.  Molecular biology and respiratory disease. 3. Evaluation of nucleolar organiser regions in pulmonary pathology.

Authors:  M J Egan; J Crocker
Journal:  Thorax       Date:  1990-03       Impact factor: 9.139

Review 2.  The dysplastic naevus.

Authors:  W J Mooi
Journal:  J Clin Pathol       Date:  1997-09       Impact factor: 3.411

Review 3.  An update on molecular alterations in melanocytic tumors with emphasis on Spitzoid lesions.

Authors:  Emmanouil Dimonitsas; Aliki Liakea; Stratigoula Sakellariou; Irene Thymara; Andreas Giannopoulos; Alexandros Stratigos; Efthymia Soura; Angelica Saetta; Penelope Korkolopoulou
Journal:  Ann Transl Med       Date:  2018-06

4.  Mutational status of naevus-associated melanomas.

Authors:  D Shitara; G Tell-Martí; C Badenas; M M S S Enokihara; L Alós; A B Larque; N Michalany; J A Puig-Butille; C Carrera; J Malvehy; S Puig; E Bagatin
Journal:  Br J Dermatol       Date:  2015-06-19       Impact factor: 9.302

5.  The dysplastic nevus: from historical perspective to management in the modern era: part I. Historical, histologic, and clinical aspects.

Authors:  Keith Duffy; Douglas Grossman
Journal:  J Am Acad Dermatol       Date:  2012-07       Impact factor: 11.527

Review 6.  [Dysplastic melanocytic nevus].

Authors:  E Bierhoff
Journal:  Pathologe       Date:  2015-02       Impact factor: 1.011

Review 7.  The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.

Authors:  Boris C Bastian
Journal:  Annu Rev Pathol       Date:  2014       Impact factor: 23.472

Review 8.  Neurotropic melanoma. A case report and review of the literature.

Authors:  E E Mack; E C Gomez
Journal:  J Neurooncol       Date:  1992-06       Impact factor: 4.130

Review 9.  [The dysplastic nevus. Separate entity, melanoma precursor or diagnostic dilemma?].

Authors:  A Roesch; M Landthaler; T Vogt
Journal:  Hautarzt       Date:  2003-09       Impact factor: 0.751

Review 10.  Melanoma risk factors and atypical moles.

Authors:  M L Williams; R W Sagebiel
Journal:  West J Med       Date:  1994-04
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