Literature DB >> 25591417

[Dysplastic melanocytic nevus].

E Bierhoff1.   

Abstract

Dysplastic nevus is still a controversial entity both clinically and histologically. The occurrence of dysplastic nevus especially in the context of dysplastic nevus cell syndrome is associated with an increased risk for melanoma. The following minimal histological criteria should be fulfilled: nests of melanocytes varying in size and shape, bridging and confluent, proliferation of single melanocytes basal and suprabasal, cytoplasmic and nuclear atypia of melanocytes and subepidermal fibroplasia. The biological behavior (common nevus variant or precursor of melanoma?) is difficult to evaluate by presently available methods. The further development of new molecular biology techniques may allow a better prognosis of dysplastic nevi in an objective and reproducible manner. Against this background complete excision followed by clinical surveillance has to be recommended for the routine practice.

Entities:  

Mesh:

Year:  2015        PMID: 25591417     DOI: 10.1007/s00292-014-2061-5

Source DB:  PubMed          Journal:  Pathologe        ISSN: 0172-8113            Impact factor:   1.011


  30 in total

1.  State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop.

Authors:  Raymond L Barnhill; Lorenzo Cerroni; Martin Cook; David E Elder; Helmut Kerl; Philip E LeBoit; Stanley W McCarthy; Martin C Mihm; Wolter J Mooi; Michael W Piepkorn; Victor G Prieto; Richard A Scolyer
Journal:  Adv Anat Pathol       Date:  2010-03       Impact factor: 3.875

2.  Genetic aspects of malignant melanoma.

Authors:  E P CAWLEY; W T KRUSE; H K PINKUS
Journal:  AMA Arch Derm Syphilol       Date:  1952-04

3.  HLA antigen expression in melanocytic lesions: is acquisition of HLA antigen expression a biomarker of atypical (dysplastic) melanocytes?

Authors:  Michael Campoli; James E Fitzpatrick; Whitney High; Soldano Ferrone
Journal:  J Am Acad Dermatol       Date:  2012-03-23       Impact factor: 11.527

Review 4.  Dysplastic nevi.

Authors:  Michele J Farber; Edward R Heilman; Robert J Friedman
Journal:  Dermatol Clin       Date:  2012-06-08       Impact factor: 3.478

Review 5.  [The dysplastic nevus. An Ariadne's thread through a conceptual labyrinth].

Authors:  P Rudolph
Journal:  Pathologe       Date:  2002-03       Impact factor: 1.011

6.  Promoter CpG island hypermethylation in dysplastic nevus and melanoma: CLDN11 as an epigenetic biomarker for malignancy.

Authors:  Linda Gao; Karin van den Hurk; Peter T M Moerkerk; Jelle J Goeman; Samuel Beck; Nelleke A Gruis; Joost J van den Oord; Véronique J Winnepenninckx; Manon van Engeland; Remco van Doorn
Journal:  J Invest Dermatol       Date:  2014-07-07       Impact factor: 8.551

7.  [DNA copy number changes in the diagnosis of melanocytic tumors].

Authors:  J Bauer; B C Bastian
Journal:  Pathologe       Date:  2007-11       Impact factor: 1.011

8.  Dysplastic nevus syndrome: a phenotypic association of sporadic cutaneous melanoma.

Authors:  D E Elder; L I Goldman; S C Goldman; M H Greene; W H Clark
Journal:  Cancer       Date:  1980-10-15       Impact factor: 6.860

9.  The significance of Melan-A-positive pagetoid melanocytosis in dysplastic nevi.

Authors:  Hassan Huwait; Nouf Hijazi; Magdalena Martinka; Richard I Crawford
Journal:  Am J Dermatopathol       Date:  2014-04       Impact factor: 1.533

10.  Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.

Authors:  Y Xu; T Brenn; E R S Brown; V Doherty; D W Melton
Journal:  Br J Cancer       Date:  2012-01-05       Impact factor: 7.640

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