Literature DB >> 30515721

Effects of Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 and Putative Probiotic Lactobacilli on DNA Damages in the Small Intestine of Wistar Rats In Vivo.

Astghik Z Pepoyan1, Marine H Balayan2, Lilit Malkhasyan2, Anahit Manvelyan3, Tatevik Bezhanyan2, Ruzanna Paronikyan2, Vardan V Tsaturyan4, Stepan Tatikyan5, Shigeru Kamiya6, Michael L Chikindas7.   

Abstract

Double-strand breaks in the DNA of the small intestine in male Wistar rats were studied using a neutral comet assay after 7 days of feeding with a single strain probiotic formulation Narine (Vitamax-E, Armenia), containing Lactobacillus acidophilus strain Er-2317/402 Narine, and putative probiotics L. rhamnosus Vahe and L. delbrueckii IAHAHI. Type 0 (undamaged DNA), type 1 (head diameter 13.18-17.08 μm), and type 2 (14.15-μm head diameter) damaged DNA comets were studied in control and lactobacilli-fed rats using the neutral comet assay. Lactobacilli-fed rats were shown to carry only type 0 (undamaged) DNA.Thus, the effects of probiotic Lactobacillus acidophilus strain INMIA 9602 Er 317/402 and putative probiotic lactobacilli on DNA damage in the small intestine of Wistar rats in vivo was shown, and the neutral comet assay is suggested as a potential tool for the in vivo selection of putative probiotics with DNA-protective activity.

Entities:  

Keywords:  Double-strand breaks of DNA; L. delbrueckii; L. rhamnosus; Neutral comet assay; Probiotic Narine; Small intestine

Mesh：

Year:  2019        PMID： 30515721     DOI： 10.1007/s12602-018-9491-y

Source DB:  PubMed          Journal:  Probiotics Antimicrob Proteins        ISSN： 1867-1306            Impact factor:   4.609


  33 in total

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7.  Next generation high throughput DNA damage detection platform for genotoxic compound screening.

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10.  Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients.

Authors:  Astghik Pepoyan; Marine Balayan; Anahit Manvelyan; Lilit Galstyan; Sofi Pepoyan; Susanna Petrosyan; Vardan Tsaturyan; Shigeru Kamiya; Tamas Torok; Michael Chikindas
Journal:  Front Immunol       Date:  2018-06-26       Impact factor: 7.561
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  3 in total

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3.  The Effect of Immunobiotic/Psychobiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Narine on Gut Prevotella in Familial Mediterranean Fever: Gender-Associated Effects.

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Journal:  Probiotics Antimicrob Proteins       Date:  2021-06-16       Impact factor: 4.609
  3 in total

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