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Literature DB >> 30482943

Tumour heterogeneity and metastasis at single-cell resolution.

Devon A Lawson^1,2, Kai Kessenbrock^3,4, Ryan T Davis⁵, Nicholas Pervolarakis^6,7, Zena Werb⁸.

Abstract

Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers, Tumor

Year: 2018 PMID： 30482943 PMCID： PMC6477686 DOI： 10.1038/s41556-018-0236-7

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

155 in total

1. Quantitative analysis of gene expression in a single cell by qPCR.

Authors: Kiyomi Taniguchi; Tomoharu Kajiyama; Hideki Kambara
Journal: Nat Methods Date: 2009-06-14 Impact factor: 28.547

2. Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells.

Authors: C A Klein; O Schmidt-Kittler; J A Schardt; K Pantel; M R Speicher; G Riethmüller
Journal: Proc Natl Acad Sci U S A Date: 1999-04-13 Impact factor: 11.205

3. The significance of hematogenous tumor cell clumps in the metastatic process.

Authors: L A Liotta; M G Saidel; J Kleinerman
Journal: Cancer Res Date: 1976-03 Impact factor: 12.701

4. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer.

Authors: Julian A Schardt; Manfred Meyer; Claudia H Hartmann; Falk Schubert; Oleg Schmidt-Kittler; Christine Fuhrmann; Bernhard Polzer; Marco Petronio; Roland Eils; Christoph A Klein
Journal: Cancer Cell Date: 2005-09 Impact factor: 31.743

Review 5. Early cancer cell dissemination and late metastatic relapse: clinical reflections and biological approaches to the dormancy problem in patients.

Authors: G Riethmüller; C A Klein
Journal: Semin Cancer Biol Date: 2001-08 Impact factor: 15.707

6. Systemic spread is an early step in breast cancer.

Authors: Yves Hüsemann; Jochen B Geigl; Falk Schubert; Piero Musiani; Manfred Meyer; Elke Burghart; Guido Forni; Roland Eils; Tanja Fehm; Gert Riethmüller; Christoph A Klein
Journal: Cancer Cell Date: 2008-01 Impact factor: 31.743

Review 7. Flow cytometric immunophenotyping for hematologic neoplasms.

Authors: Fiona E Craig; Kenneth A Foon
Journal: Blood Date: 2008-01-15 Impact factor: 22.113

8. From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression.

Authors: Oleg Schmidt-Kittler; Thomas Ragg; Angela Daskalakis; Martin Granzow; Andre Ahr; Thomas J F Blankenstein; Manfred Kaufmann; Joachim Diebold; Hans Arnholdt; Peter Muller; Joachim Bischoff; Detlev Harich; Gunter Schlimok; Gert Riethmuller; Roland Eils; Christoph A Klein
Journal: Proc Natl Acad Sci U S A Date: 2003-06-13 Impact factor: 11.205

Review 9. Metastasis: from dissemination to organ-specific colonization.

Authors: Don X Nguyen; Paula D Bos; Joan Massagué
Journal: Nat Rev Cancer Date: 2009-04 Impact factor: 60.716

10. Efficient tumour formation by single human melanoma cells.

Authors: Elsa Quintana; Mark Shackleton; Michael S Sabel; Douglas R Fullen; Timothy M Johnson; Sean J Morrison
Journal: Nature Date: 2008-12-04 Impact factor: 49.962

123 in total

1. Volumetric stimulated Raman scattering imaging of cleared tissues towards three-dimensional chemical histopathology.

Authors: Junjie Li; Peng Lin; Yuying Tan; Ji-Xin Cheng
Journal: Biomed Opt Express Date: 2019-08-01 Impact factor: 3.732

2. Radiomics based on multisequence magnetic resonance imaging for the preoperative prediction of peritoneal metastasis in ovarian cancer.

Authors: Xiao-Li Song; Jia-Liang Ren; Ting-Yu Yao; Dan Zhao; Jinliang Niu
Journal: Eur Radiol Date: 2021-05-04 Impact factor: 5.315

Review 3. Molecular principles of metastasis: a hallmark of cancer revisited.

Authors: Jawad Fares; Mohamad Y Fares; Hussein H Khachfe; Hamza A Salhab; Youssef Fares
Journal: Signal Transduct Target Ther Date: 2020-03-12

Review 4. Addressing Patient Specificity in the Engineering of Tumor Models.

Authors: Laura J Bray; Dietmar W Hutmacher; Nathalie Bock
Journal: Front Bioeng Biotechnol Date: 2019-09-12

5. Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.

Authors: Lindsay M LaFave; Vinay K Kartha; Sai Ma; Kevin Meli; Isabella Del Priore; Caleb Lareau; Santiago Naranjo; Peter M K Westcott; Fabiana M Duarte; Venkat Sankar; Zachary Chiang; Alison Brack; Travis Law; Haley Hauck; Annalisa Okimoto; Aviv Regev; Jason D Buenrostro; Tyler Jacks
Journal: Cancer Cell Date: 2020-07-23 Impact factor: 31.743