SCOPE: The gut microbiota ellagitannin-metabolizing phenotypes (i.e., urolithin metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk biomarkers because the host blood lipid profile is reported to be associated with specific UMs. However, the link for this association remains unknown so far. METHODS AND RESULTS: The gut microbiome of 249 healthy individuals is analyzed using 16S rDNA sequencing analysis. Individuals are also stratified by UMs (UM-A, UM-B, and UM-0) and enterotypes (Bacteroides, Prevotella, and Ruminococcus). Associations of UMs discriminating bacteria with CVD risk markers are investigated. Distribution and gut microbiota composition of UMs and enterotypes are not coincident. Almost half of the discriminating genera between UM-A and UM-B belongs to the Coriobacteriaceae family. UM-B individuals present higher blood cholesterol levels and higher alpha-diversity, including Coriobacteriaceae family, than those of UM-A. Coriobacteriaceae, whose abundance is the highest in UM-B, is positively correlated with total cholesterol, LDL cholesterol, and body mass index. CONCLUSIONS: Results herein suggest that the family Coriobacteriaceae could be a link between individuals' UMs and their blood cholesterol levels. Further research is needed to explore the mechanisms of the host metabolic phenotype, including cholesterol excretion products, to modulate this bacterial family.
SCOPE: The gut microbiota ellagitannin-metabolizing phenotypes (i.e., urolithin metabotypes [UMs]) are proposed as potential cardiovascular disease (CVD) risk biomarkers because the host blood lipid profile is reported to be associated with specific UMs. However, the link for this association remains unknown so far. METHODS AND RESULTS: The gut microbiome of 249 healthy individuals is analyzed using 16S rDNA sequencing analysis. Individuals are also stratified by UMs (UM-A, UM-B, and UM-0) and enterotypes (Bacteroides, Prevotella, and Ruminococcus). Associations of UMs discriminating bacteria with CVD risk markers are investigated. Distribution and gut microbiota composition of UMs and enterotypes are not coincident. Almost half of the discriminating genera between UM-A and UM-B belongs to the Coriobacteriaceae family. UM-B individuals present higher blood cholesterol levels and higher alpha-diversity, including Coriobacteriaceae family, than those of UM-A. Coriobacteriaceae, whose abundance is the highest in UM-B, is positively correlated with total cholesterol, LDL cholesterol, and body mass index. CONCLUSIONS: Results herein suggest that the family Coriobacteriaceae could be a link between individuals' UMs and their blood cholesterol levels. Further research is needed to explore the mechanisms of the host metabolic phenotype, including cholesterol excretion products, to modulate this bacterial family.
Authors: Rhonda L Bitting; Janet A Tooze; Scott Isom; W Jeffrey Petty; Stefan C Grant; Rodwige J Desnoyers; Alexandra Thomas; Christopher Y Thomas; Angela T Alistar; Shannon L Golden; Katherine Pleasant; Mark C Chappell; E Ann Tallant; Patricia E Gallagher; Heidi D Klepin Journal: Am J Clin Oncol Date: 2021-06-01 Impact factor: 2.787
Authors: Adrián Cortés-Martín; María Romo-Vaquero; Izaskun García-Mantrana; Ana Rodríguez-Varela; María Carmen Collado; Juan Carlos Espín; María Victoria Selma Journal: Nutrients Date: 2019-09-03 Impact factor: 5.717
Authors: Rikard Landberg; Claudine Manach; Frederiek-Maarten Kerckhof; Anne-Marie Minihane; Rasha Noureldin M Saleh; Baukje De Roos; Francisco Tomas-Barberan; Christine Morand; Tom Van de Wiele Journal: Eur J Nutr Date: 2019-10-23 Impact factor: 5.614
Authors: Izaskun García-Mantrana; Marta Calatayud; María Romo-Vaquero; Juan Carlos Espín; María V Selma; María Carmen Collado Journal: Nutrients Date: 2019-10-16 Impact factor: 5.717
Authors: Kristen M Roberts; Elizabeth M Grainger; Jennifer M Thomas-Ahner; Alice Hinton; Junnan Gu; Ken Riedl; Yael Vodovotz; Ronney Abaza; Steven J Schwartz; Steven K Clinton Journal: Mol Nutr Food Res Date: 2020-03-17 Impact factor: 6.575