Literature DB >> 30456164

Efficacy of Chitosan in promoting wound healing in extraction socket: A prospective study.

Akshat Gupta1, Vidya Rattan1, Sachin Rai1.   

Abstract

PURPOSE: Chitosan has been shown to promote wound healing and induce bone formation. The aim of this split-mouth study was to evaluate the effectiveness of chitosan based dressing in wound healing after lower third molar extraction.
METHOD: Asymptomatic symmetrical mandibular third molars were extracted simultaneously in 27 patients and Chitosan dressing was placed into the extraction socket in the test side. Pain scores were recorded on VAS using a 0 to 10 pain score. Wound healing was compared between right and left side. Radiographic findings were evaluated by observing lamina dura and density of extraction socket.
RESULTS: Test group had more pain than control at all time intervals and unerupted tooth sites showed mean pain score significantly more than erupted tooth sites. Test group was superior to control in event of wound healing. Healing was significantly better in erupted tooth than unerupted tooth. At second week 12 sites showed better radiographic findings in chitosan treated group compared to 3 sites in the control group. At third month, 14 sites showed improved bone formation in chitosan treated group compared to 4 in control group. None of the unerupted teeth group showed better radiographic finding in test side at 2 week and 3 month compared to erupted teeth group.
CONCLUSION: Chitosan is effective in promoting wound healing and early osteogenesis in erupted tooth socket after extraction. We recommend that chitosan dressing should be used in the sockets of erupted tooth after extraction but should be avoided in unerupted or impacted teeth cases.

Entities:  

Keywords:  Chitosan; Dry socket; Extraction socket; Impacted third molar

Year:  2018        PMID: 30456164      PMCID: PMC6234520          DOI: 10.1016/j.jobcr.2018.11.001

Source DB:  PubMed          Journal:  J Oral Biol Craniofac Res        ISSN: 2212-4268


  17 in total

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Authors:  H Ueno; T Mori; T Fujinaga
Journal:  Adv Drug Deliv Rev       Date:  2001-11-05       Impact factor: 15.470

Review 2.  Chitosan as antimicrobial agent: applications and mode of action.

Authors:  Entsar I Rabea; Mohamed E-T Badawy; Christian V Stevens; Guy Smagghe; Walter Steurbaut
Journal:  Biomacromolecules       Date:  2003 Nov-Dec       Impact factor: 6.988

3.  Types, frequencies, and risk factors for complications after third molar extraction.

Authors:  Chi H Bui; Edward B Seldin; Thomas B Dodson
Journal:  J Oral Maxillofac Surg       Date:  2003-12       Impact factor: 1.895

Review 4.  Biomaterials based on chitin and chitosan in wound dressing applications.

Authors:  R Jayakumar; M Prabaharan; P T Sudheesh Kumar; S V Nair; H Tamura
Journal:  Biotechnol Adv       Date:  2011-01-22       Impact factor: 14.227

Review 5.  Dental extraction wound management: medicating postextraction sockets.

Authors:  P J Vezeau
Journal:  J Oral Maxillofac Surg       Date:  2000-05       Impact factor: 1.895

Review 6.  New Frontiers in Biomaterials.

Authors:  R Gilbert Triplett; Oksana Budinskaya
Journal:  Oral Maxillofac Surg Clin North Am       Date:  2017-02       Impact factor: 2.802

7.  Initial study on facilitating wound healing after tooth extraction by using microbial fiber membrane-flagyl.

Authors:  Yan Qiu Li; Zeng Chun Shan
Journal:  J Oral Maxillofac Surg       Date:  2010-10-20       Impact factor: 1.895

8.  An alternative hemostatic dressing: comparison of CELOX, HemCon, and QuikClot.

Authors:  Buddy G Kozen; Sara J Kircher; Jose Henao; Fermin S Godinez; Andrew S Johnson
Journal:  Acad Emerg Med       Date:  2008-01       Impact factor: 3.451

9.  Hemostasis of oral surgery wounds with the HemCon Dental Dressing.

Authors:  Jay P Malmquist; Stephen C Clemens; Hal J Oien; Sharon L Wilson
Journal:  J Oral Maxillofac Surg       Date:  2008-06       Impact factor: 1.895

10.  Antibacterial action of a novel functionalized chitosan-arginine against Gram-negative bacteria.

Authors:  Hong Tang; Peng Zhang; Thomas L Kieft; Shannon J Ryan; Shenda M Baker; William P Wiesmann; Snezna Rogelj
Journal:  Acta Biomater       Date:  2010-01-11       Impact factor: 8.947

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  5 in total

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Journal:  Int J Mol Sci       Date:  2019-10-09       Impact factor: 5.923

Review 2.  Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles.

Authors:  Balsam R Rizeq; Nadin N Younes; Kashif Rasool; Gheyath K Nasrallah
Journal:  Int J Mol Sci       Date:  2019-11-16       Impact factor: 5.923

3.  Preparation of a nanopearl powder/C-HA (chitosan-hyaluronic acid)/rhBMP-2 (recombinant human bone morphogenetic protein-2) composite artificial bone material and a preliminary study of its effects on MC3T3-E1 cells.

Authors:  Wenbo Zhang; Pu Xu; Yanan Cheng; Yanlan Yang; Qiuhua Mao; Zuogeng Chen
Journal:  Bioengineered       Date:  2022-06       Impact factor: 6.832

4.  Efficacy of plasma rich in growth factor used for dry socket management: a systematic review.

Authors:  J-L Xu; R Xia
Journal:  Med Oral Patol Oral Cir Bucal       Date:  2019-11-01

5.  Effectiveness of a Nanohydroxyapatite-Based Hydrogel on Alveolar Bone Regeneration in Post-Extraction Sockets of Dogs with Naturally Occurring Periodontitis.

Authors:  Kittidaj Tanongpitchayes; Chamnan Randorn; Suphatchaya Lamkhao; Komsanti Chokethawai; Gobwute Rujijanagul; Kannika Na Lampang; Luddawon Somrup; Chavalit Boonyapakorn; Kriangkrai Thongkorn
Journal:  Vet Sci       Date:  2021-12-26
  5 in total

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