Literature DB >> 30453246

Thiazole, thio and semicarbazone derivatives against tropical infective diseases: Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria.

Cauê Benito Scarim1, Daniela Hartmann Jornada2, Marcella Gabrielle Mendes Machado2, Carla Maria Riberio Ferreira2, Jean Leandro Dos Santos2, Man Chin Chung3.   

Abstract

Thiazole, thiosemicarbazone and semicarbazone moieties are privileged scaffolds (acting as primary pharmacophores) in many compounds that are useful to treat several diseases, mainly tropical infectious diseases. In this review article, we critically analyzed the contribution of these scaffolds to medicinal chemistry in the last five years, focusing on tropical infectious diseases, such as Chagas disease, human African trypanosomiasis (HAT), leishmaniasis, and malaria. We also present perspectives for their use in drug design in order to contribute to the development of new drugs.
Copyright © 2018 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Chagas disease; Drug development; New drugs; Semicarbazone; T. cruzi; Thiazole; Thiosemicarbazone

Mesh：

Substances：

Year:  2018        PMID： 30453246     DOI： 10.1016/j.ejmech.2018.11.013

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

1.  New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Follow-Up.

Authors:  María Gabriela Álvarez; Juan Carlos Ramírez; Graciela Bertocchi; Marisa Fernández; Yolanda Hernández; Bruno Lococo; Constanza Lopez-Albizu; Alejandro Schijman; Carolina Cura; Marcelo Abril; Susana Laucella; Rick L Tarleton; María Ailen Natale; Melisa Castro Eiro; Sergio Sosa-Estani; Rodolfo Viotti
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

2.  In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches.

Authors:  Lina S Prieto Cárdenas; Karen A Arias Soler; Diana L Nossa González; Wilson E Rozo Núñez; Agobardo Cárdenas-Chaparro; Pablo R Duchowicz; Jovanny A Gómez Castaño
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-31

3.  Synthesis, Structures, and Solution Studies of a New Class of [Mo2O2S2]-Based Thiosemicarbazone Coordination Complexes.

Authors:  Arcadie Fuior; Diana Cebotari; Mohamed Haouas; Jérôme Marrot; Guillermo Minguez Espallargas; Vincent Guérineau; David Touboul; Roman V Rusnac; Aurelian Gulea; Sébastien Floquet
Journal:  ACS Omega       Date:  2022-05-03

4.  Synthesis, crystal structure and antiproliferative mechanisms of gallium(iii) complexes with benzoylpyridine thiosemicarbazones.

Authors:  Jinxu Qi; Taichen Liu; Wei Zhao; Xinhua Zheng; Yihong Wang
Journal:  RSC Adv       Date:  2020-05-18       Impact factor: 4.036

5.  New dicationic DABCO-based ionic liquids: a scalable metal-free one-pot synthesis of bis-2-amino-5-arylidenethiazol-4-ones.

Authors:  Wael A A Arafa; Asmaa K Mourad
Journal:  R Soc Open Sci       Date:  2019-07-24       Impact factor: 2.963

6.  Trypanocidal Mechanism of Action and in silico Studies of p-Coumaric Acid Derivatives.

Authors:  Susiany P Lopes; Yunierkis P Castillo; Marilia L Monteiro; Ramon R P P B de Menezes; Reinaldo N Almeida; Alice M C Martins; Damião P de Sousa
Journal:  Int J Mol Sci       Date:  2019-11-25       Impact factor: 5.923

Review 7.  An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives.

Authors:  Anca-Maria Borcea; Ioana Ionuț; Ovidiu Crișan; Ovidiu Oniga
Journal:  Molecules       Date:  2021-01-25       Impact factor: 4.411

8.  Hybrid Quinoline-Thiosemicarbazone Therapeutics as a New Treatment Opportunity for Alzheimer's Disease‒Synthesis, In Vitro Cholinesterase Inhibitory Potential and Computational Modeling Analysis.

Authors:  Sumera Zaib; Rubina Munir; Muhammad Tayyab Younas; Naghmana Kausar; Aliya Ibrar; Sehar Aqsa; Noorma Shahid; Tahira Tasneem Asif; Hashem O Alsaab; Imtiaz Khan
Journal:  Molecules       Date:  2021-10-30       Impact factor: 4.411

9.  Methodological Appraisal of Literature Concerning the Analysis of Genetic Variants or Protein Levels of Complement Components on Susceptibility to Infection by Trypanosomatids: A Systematic Review.

Authors:  Thais Cristina Tirado; Larine Lowry Moura; Patrícia Shigunov; Fabiano Borges Figueiredo
Journal:  Front Immunol       Date:  2021-11-25       Impact factor: 7.561

10.  Synthesis and evaluation of novel 2,4-disubstituted arylthiazoles against T. brucei.

Authors:  Markos-Orestis Georgiadis; Violeta Kourbeli; Ioannis P Papanastasiou; Andrew Tsotinis; Martin C Taylor; John M Kelly
Journal:  RSC Med Chem       Date:  2019-12-19
  10 in total

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