| Literature DB >> 30452639 |
Azeez Butali1, Peter A Mossey2, Wasiu L Adeyemo3, Mekonen A Eshete4, Lord J J Gowans5, Tamara D Busch1, Deepti Jain6, Wenjie Yu7, Liu Huan8, Cecelia A Laurie6, Cathy C Laurie6, Sarah Nelson6, Mary Li1, Pedro A Sanchez-Lara9, William P Magee10, Kathleen S Magee11, Allyn Auslander10, Frederick Brindopke10, Denise M Kay12, Michele Caggana12, Paul A Romitti13, James L Mills14, Rosemary Audu15, Chika Onwuamah15, Ganiyu O Oseni16, Arwa Owais17, Olutayo James3, Peter B Olaitan16, Babatunde S Aregbesola18, Ramat O Braimah19, Fadekemi O Oginni18, Ayodeji O Oladele18, Saidu A Bello20, Jennifer Rhodes21, Rita Shiang21, Peter Donkor5, Solomon Obiri-Yeboah5, Fareed Kow Nanse Arthur5, Peter Twumasi5, Pius Agbenorku5, Gyikua Plange-Rhule5, Alexander Acheampong Oti5, Olugbenga M Ogunlewe3, Afisu A Oladega3, Adegbayi A Adekunle3, Akinwunmi O Erinoso3, Olatunbosun O Adamson3, Abosede A Elufowoju3, Oluwanifemi I Ayelomi3, Taiye Hailu4, Abiye Hailu4, Yohannes Demissie4, Miliard Derebew4, Steve Eliason7, Miguel Romero-Bustillous7, Cynthia Lo1, James Park1, Shaan Desai1, Muiawa Mohammed1, Firke Abate4, Lukman O Abdur-Rahman22, Deepti Anand23, Irfaan Saadi24, Abimibola V Oladugba25, Salil A Lachke23, Brad A Amendt7, Charles N Rotimi26, Mary L Marazita27, Robert A Cornell7, Jeffrey C Murray28, Adebowale A Adeyemo26.
Abstract
Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in mice showed expression of SULT2A1 in mesenchymal cells in palate, palatal rugae and palatal epithelium in the fused palate. The previously reported 8q24 was the most significant locus for CL/P in our study, and we replicated several previously reported loci including PAX7 and VAX1. Published by Oxford University Press 2018.Entities:
Mesh：
Year: 2019 PMID： 30452639 PMCID： PMC6400042 DOI： 10.1093/hmg/ddy402
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150