Literature DB >> 30443654

A guide to maximizing the therapeutic potential of protein-polymer conjugates by rational design.

Jeong Hoon Ko1, Heather D Maynard.   

Abstract

Proteins are an important class of therapeutics that have advantages including high target specificity, but challenges to their use include rapid clearance and low physical stability. Conjugation of synthetic polymers is an effective approach to address the drawbacks and enhance other properties such as solubility. In this review, we present various considerations in synthesizing protein-polymer conjugates for therapeutic applications with a focus on the choice of polymer, protein, and conjugation method, as well as characterization and evaluation of the resulting conjugate in order to maximize the therapeutic potential of the protein drug.

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Year:  2018        PMID： 30443654      PMCID： PMC6322549          DOI： 10.1039/c8cs00606g

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  48 in total

1.  The Protein Data Bank.

Authors:  H M Berman; J Westbrook; Z Feng; G Gilliland; T N Bhat; H Weissig; I N Shindyalov; P E Bourne
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

2.  Site-specific insulin conjugates with enhanced stability and extended action profile.

Authors: 
Journal:  Adv Drug Deliv Rev       Date:  1999-02-01       Impact factor: 15.470

3.  Streptavidin as a macroinitiator for polymerization: in situ protein-polymer conjugate formation.

Authors:  Debora Bontempo; Heather D Maynard
Journal:  J Am Chem Soc       Date:  2005-05-11       Impact factor: 15.419

Review 4.  Protein therapeutics: a summary and pharmacological classification.

Authors:  Benjamin Leader; Quentin J Baca; David E Golan
Journal:  Nat Rev Drug Discov       Date:  2008-01       Impact factor: 84.694

5.  In situ growth of side-chain PEG polymers from functionalized human growth hormone-a new technique for preparation of enhanced protein-polymer conjugates.

Authors:  Johannes Pall Magnusson; Sara Bersani; Stefano Salmaso; Cameron Alexander; Paolo Caliceti
Journal:  Bioconjug Chem       Date:  2010-04-21       Impact factor: 4.774

6.  Disulfide-linked antibody-maytansinoid conjugates: optimization of in vivo activity by varying the steric hindrance at carbon atoms adjacent to the disulfide linkage.

Authors:  Brenda A Kellogg; Lisa Garrett; Yelena Kovtun; Katharine C Lai; Barbara Leece; Michael Miller; Gillian Payne; Rita Steeves; Kathleen R Whiteman; Wayne Widdison; Hongsheng Xie; Rajeeva Singh; Ravi V J Chari; John M Lambert; Robert J Lutz
Journal:  Bioconjug Chem       Date:  2011-03-22       Impact factor: 4.774

7.  A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate].

Authors:  W N van Dijk-Wolthuis; P van de Wetering; W L Hinrichs; L J Hofmeyer; R M Liskamp; D J Crommelin; W E Hennink
Journal:  Bioconjug Chem       Date:  1999 Jul-Aug       Impact factor: 4.774

Review 8.  The dawning era of polymer therapeutics.

Authors:  Ruth Duncan
Journal:  Nat Rev Drug Discov       Date:  2003-05       Impact factor: 84.694

Review 9.  Mono-N-terminal poly(ethylene glycol)-protein conjugates.

Authors:  Olaf Kinstler; Graham Molineux; Michael Treuheit; David Ladd; Colin Gegg
Journal:  Adv Drug Deliv Rev       Date:  2002-06-17       Impact factor: 15.470

10.  HPMA copolymers: origins, early developments, present, and future.

Authors:  Jindrich Kopecek; Pavla Kopecková
Journal:  Adv Drug Deliv Rev       Date:  2009-11-14       Impact factor: 15.470
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  12 in total

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Authors:  Nahal Habibi; Ava Mauser; Yeongun Ko; Joerg Lahann
Journal:  Adv Sci (Weinh)       Date:  2022-01-25       Impact factor: 16.806

2.  Machine Learning on a Robotic Platform for the Design of Polymer-Protein Hybrids.

Authors:  Matthew J Tamasi; Roshan A Patel; Carlos H Borca; Shashank Kosuri; Heloise Mugnier; Rahul Upadhya; N Sanjeeva Murthy; Michael A Webb; Adam J Gormley
Journal:  Adv Mater       Date:  2022-06-11       Impact factor: 32.086

3.  Site-Specific Cross-Linking of Galectin-1 Homodimers via Poly(ethylene glycol) Bismaleimide.

Authors:  Bryant J Kane; Margaret M Fettis; Shaheen A Farhadi; Renjie Liu; Gregory A Hudalla
Journal:  Cell Mol Bioeng       Date:  2021-06-04       Impact factor: 3.337

4.  Preparation of Biomolecule-Polymer Conjugates by Grafting-From Using ATRP, RAFT, or ROMP.

Authors:  Marco S Messina; Kathryn M M Messina; Arvind Bhattacharya; Hayden R Montgomery; Heather D Maynard
Journal:  Prog Polym Sci       Date:  2019-11-18       Impact factor: 29.190

5.  Hetero-Diels-Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform.

Authors:  Ana Beloqui; Shivshankar R Mane; Marcel Langer; Mathias Glassner; Dennis M Bauer; Ljiljana Fruk; Christopher Barner-Kowollik; Guillaume Delaittre
Journal:  Angew Chem Int Ed Engl       Date:  2020-09-02       Impact factor: 15.336

6.  Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates.

Authors:  Meri Ayurini; Peter G Chandler; Paul D O'Leary; Ruoxin Wang; David Rudd; Karen D Milewska; Lara R Malins; Ashley M Buckle; Joel F Hooper
Journal:  JACS Au       Date:  2021-11-30

7.  Automated prediction of site and sequence of protein modification with ATRP initiators.

Authors:  Arth Patel; Paige N Smith; Alan J Russell; Sheiliza Carmali
Journal:  PLoS One       Date:  2022-09-19       Impact factor: 3.752

Review 8.  Automation and data-driven design of polymer therapeutics.

Authors:  Rahul Upadhya; Shashank Kosuri; Matthew Tamasi; Travis A Meyer; Supriya Atta; Michael A Webb; Adam J Gormley
Journal:  Adv Drug Deliv Rev       Date:  2020-11-24       Impact factor: 15.470

9.  Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach.

Authors:  Alexis Theodorou; Evelina Liarou; David M Haddleton; Iren Georgia Stavrakaki; Panagiotis Skordalidis; Richard Whitfield; Athina Anastasaki; Kelly Velonia
Journal:  Nat Commun       Date:  2020-03-20       Impact factor: 14.919

Review 10.  Nanohybrids as Protein-Polymer Conjugate Multimodal Therapeutics.

Authors:  Pallavi Kiran; Amreen Khan; Suditi Neekhra; Shubham Pallod; Rohit Srivastava
Journal:  Front Med Technol       Date:  2021-09-08
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