Literature DB >> 30344446

A Convergent, Enantioselective Total Synthesis of Hapalosin: A Drug with Multidrug-Resistance Reversing Activity.

Arun K Ghosh1, Wenming Liu1, Yibo Xu1, Zhidong Chen1.   

Abstract

Entities:  

Keywords:  chemotherapy; hapalosin; natural products; total syntheses

Year:  1996        PMID： 30344446      PMCID： PMC6195359          DOI： 10.1002/anie.199600741

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  6 in total

Review 1.  Multidrug resistance.

Authors:  I Pastan; M M Gottesman
Journal:  Annu Rev Med       Date:  1991       Impact factor: 13.739

2.  Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

Authors:  W J Thompson; P M Fitzgerald; M K Holloway; E A Emini; P L Darke; B M McKeever; W A Schleif; J C Quintero; J A Zugay; T J Tucker
Journal:  J Med Chem       Date:  1992-05-15       Impact factor: 7.446

Review 3.  The biochemistry of P-glycoprotein-mediated multidrug resistance.

Authors:  J A Endicott; V Ling
Journal:  Annu Rev Biochem       Date:  1989       Impact factor: 23.643

4.  Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

Authors:  R F Ozols; R E Cunnion; R W Klecker; T C Hamilton; Y Ostchega; J E Parrillo; R C Young
Journal:  J Clin Oncol       Date:  1987-04       Impact factor: 44.544

5.  Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Authors:  A K Ghosh; W J Thompson; M K Holloway; S P McKee; T T Duong; H Y Lee; P M Munson; A M Smith; J M Wai; P L Darke
Journal:  J Med Chem       Date:  1993-08-06       Impact factor: 7.446

6.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

Authors:  N Kartner; J R Riordan; V Ling
Journal:  Science       Date:  1983-09-23       Impact factor: 47.728
  6 in total
  3 in total

1.  A Convenient Enzymatic Route to Optically Active l-Aminoindan-2-ol: Versatile Ligands for HIV-1 Protease Inhibitors and Asymmetric Syntheses.

Authors:  Arun K Ghosh; John F Kincaid; Michael G Haske
Journal:  Synthesis (Stuttg)       Date:  1997-05       Impact factor: 3.157

2.  Synthesis of Bioactive Natural Products by Asymmetric syn- and anti-Aldol Reactions.

Authors:  Arun K Ghosh; Zachary L Dawson
Journal:  Synthesis (Stuttg)       Date:  2009-09       Impact factor: 3.157

3.  Asymmetric alkylations and aldol reactions: (1S,2R)-2-aminocyclopentan-1-ol derived new chiral auxiliary.

Authors:  Arun K Ghosh; Hanna Cho; Masanobu Onishi
Journal:  Tetrahedron Asymmetry       Date:  1997-03-27
  3 in total

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