Cole C Meyer1, Eliezer Ortiz1, Michael J Krische1. 1. Department of Chemistry, University of Texas at Austin, Welch Hall (A5300), 105 East 24th Street, Austin, Texas 78712, United States.
Abstract
Catalytic reductive coupling of enone, acrylate, or vinyl heteroaromatic pronucleophiles with carbonyl or imine partners offers an alternative to base-mediated enolization in aldol- and Mannich-type reactions. In this review, direct catalytic reductive aldol and Mannich reactions are exhaustively catalogued on the basis of metal or organocatalyst. Stepwise processes involving enone conjugate reduction to form discrete enol or (metallo)enolate derivatives followed by introduction of carbonyl or imine electrophiles and aldol reactions initiated via enone conjugate addition are not covered.
Catalytic reductive coupling of enone, n class="Chemical">acrylate, or vinyl heteroaromatic pronucleophiles with carbonyl orimine partners offers an alternative to base-mediated enolization in aldol- and Mannich-type reactions. In this review, direct catalytic reductive aldol and Mannich reactions are exhaustively catalogued on the basis of metal or organocatalyst. Stepwise processes involving enone conjugate reduction to form discrete enol or (metallo)enolate derivatives followed by introduction of carbonyl orimine electrophiles and aldol reactions initiated via enone conjugate addition are not covered.