Lucas Jurado-Fasoli1, Francisco J Amaro-Gahete2, Alejandro De-la-O3, Ángel Gutiérrez3, Manuel J Castillo4. 1. Department of Medical Physiology, School of Medicine, University of Granada, Spain. Electronic address: juradofasoli@ugr.es. 2. Department of Medical Physiology, School of Medicine, University of Granada, Spain; PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain. 3. Department of Medical Physiology, School of Medicine, University of Granada, Spain. 4. Department of Medical Physiology, School of Medicine, University of Granada, Spain. Electronic address: mcgarzon@ugr.es.
Abstract
INTRODUCTION:Alcohol consumption is related to several diseases and injuries that accelerate the ageing process and increase the mortality and morbidity risk. The soluble form of the α-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker. AIM: The aim of the present study was to analyze the association between alcohol consumption and S-Klotho plasma levels in sedentary middle-aged adults. METHODS: 74 (39 women) middle-aged sedentary adults (40-65 years old) participated in the present study. Alcohol consumption was assessed with a food frequency questionnaire previously validated and with three non-consecutive 24-hours recall. The S-Klotho plasma levels were measured by ELISA using a soluble α-Klotho ELISA assay kit. RESULTS:Total alcoholic drinks consumption was negatively associated with S-Klotho plasma levels (β=-17.031; R2 = 0.096, P = 0.013). Furthermore, we observed that higher consumption of total alcoholic drinks is associated with lower S-Klotho plasma levels in middle-aged sedentary adults controlling for BMI (β=-16.372; R2 = 0.201, P = 0.011), LMI (β=-31.854; R2 = 0.305, P = 0.010) and for FMI β=-13.337; R2 = 0.075, P = 0.049). CONCLUSION: In conclusion, our study shows that total alcoholic drinks consumption is negatively associated with the S-Klotho plasma levels in middle-aged sedentary adults.
RCT Entities:
INTRODUCTION:Alcohol consumption is related to several diseases and injuries that accelerate the ageing process and increase the mortality and morbidity risk. The soluble form of the α-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker. AIM: The aim of the present study was to analyze the association between alcohol consumption and S-Klotho plasma levels in sedentary middle-aged adults. METHODS: 74 (39 women) middle-aged sedentary adults (40-65 years old) participated in the present study. Alcohol consumption was assessed with a food frequency questionnaire previously validated and with three non-consecutive 24-hours recall. The S-Klotho plasma levels were measured by ELISA using a soluble α-Klotho ELISA assay kit. RESULTS: Total alcoholic drinks consumption was negatively associated with S-Klotho plasma levels (β=-17.031; R2 = 0.096, P = 0.013). Furthermore, we observed that higher consumption of total alcoholic drinks is associated with lower S-Klotho plasma levels in middle-aged sedentary adults controlling for BMI (β=-16.372; R2 = 0.201, P = 0.011), LMI (β=-31.854; R2 = 0.305, P = 0.010) and for FMI β=-13.337; R2 = 0.075, P = 0.049). CONCLUSION: In conclusion, our study shows that total alcoholic drinks consumption is negatively associated with the S-Klotho plasma levels in middle-aged sedentary adults.
Authors: Charat Thongprayoon; Javier A Neyra; Panupong Hansrivijit; Juan Medaura; Napat Leeaphorn; Paul W Davis; Wisit Kaewput; Tarun Bathini; Sohail Abdul Salim; Api Chewcharat; Narothama Reddy Aeddula; Saraschandra Vallabhajosyula; Michael A Mao; Wisit Cheungpasitporn Journal: J Clin Med Date: 2020-06-12 Impact factor: 4.241