Literature DB >> 30419337

Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease.

E Sandra Chocron1, Erin Munkácsy1, Andrew M Pickering2.   

Abstract

The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome, comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation and the mitochondrial translation machinery. Despite its small size, much interest has developed in recent years regarding the role of mtDNA as a determinant of both aging and age-associated diseases. A number of studies have presented compelling evidence for key roles of mtDNA in age-related pathology, although many are correlative rather than demonstrating cause. In this review we will evaluate the evidence supporting and opposing a role for mtDNA in age-associated functional declines and diseases. We provide an overview of mtDNA biology, damage and repair as well as the influence of mitochondrial haplogroups, epigenetics and maternal inheritance in aging and longevity.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Aging; Lifespan; Mitochondria; mtDNA

Mesh：

Substances：

Year:  2018        PMID： 30419337      PMCID： PMC6310633          DOI： 10.1016/j.bbadis.2018.09.035

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Basis Dis        ISSN： 0925-4439            Impact factor:   5.187


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