| Literature DB >> 2390073 |
S Ikebe1, M Tanaka, K Ohno, W Sato, K Hattori, T Kondo, Y Mizuno, T Ozawa.
Abstract
A mutant mitochondrial DNA (mtDNA) with a 4,977-bp deletion was detected in the parkinsonian brain by using the polymerase chain reaction. Although the deleted mtDNA was detectable even in the brain of aged controls, the proportion of deleted mtDNA to normal mtDNA in the striatum was higher in the parkinsonian patients than in the controls. In both the parkinsonian patients and the aged controls, the proportion was higher in the striatum than in the cerebral cortex. These results indicate that age-related accumulation of deleted mtDNA is accelerated in the parkinsonian striatum and suggest that the deletion contributes to pathophysiological processes underlying Parkinson's disease.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2390073 DOI： 10.1016/0006-291x(90)90497-b
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575