Minji Jang1, Hyung Woo Park2, Jimi Huh3,4, Jong Hwa Lee1, Yoong Ki Jeong1, Yang Won Nah2, Jisuk Park5, Kyung Won Kim5. 1. Department of Radiology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, South Korea. 2. Department of Surgery, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, South Korea. 3. Department of Radiology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, South Korea. jimihuh.rad@gmail.com. 4. Department of Radiology, Ajou University School of Medicine & Graduate School of Medicine, Ajou University Medical Center, 164 World cup-ro, Yeongtong-gu, Suwon, 16499, South Korea. jimihuh.rad@gmail.com. 5. Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
Abstract
OBJECTIVE: To evaluate predictive values of sarcopenia and visceral obesity measured from preoperative CT/MRIs for postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy in patients with periampullary malignancies. METHODS: From the prospectively constructed surgical registry, we included adult patients treated with pancreaticoduodenectomy. Based on CT/MRIs, body morphometric analysis was performed to evaluate the visceral obesity and sarcopenia, based on the areas of visceral fat and skeletal muscle measured at the L3 vertebrae level. We retrieved various perioperative factors from registry. As outcomes of postoperative complications, we evaluated POPF and major complications based on the Clavien-Dindo classification. Multivariate logistic regression analyses were performed. RESULTS: From a total of 284 patients (163 males, 121 females) who met the inclusion/exclusion criteria, POPF, major complications, and 60-day mortality occurred in 52 (18.3%), 34 (12.0%), and 6 (2.1%), respectively. Sarcopenia and visceral obesity were noted in 123 (75.5%) and 66 (40.5%) of men and 68 (56.2%) and 53 (43.8%) of women, respectively. Combination of sarcopenia and obesity (sarcopenic obesity) was noted in 31.9% (52/163) of men and in 26.4% (32/121) of women. In multivariate logistic regression analyses, sarcopenic obesity was the only independent predictor for POPF (OR 2.65, 95% CI 1.43-4.93), and the vascular resection during pancreaticoduodenectomy was the only independent predictor for severe complications (OR 3.75, 95% CI 1.61-8.70). CONCLUSION: Sarcopenic obesity might be highly predictive for POPF. Body morphometric analysis in preoperative CT/MRI combined with assessment of perioperative clinical features may help to identify high-risk patients and determine perioperative management strategies. KEY POINTS: • Sarcopenic obesity might be predictive for postoperative pancreatic fistula after pancreaticoduodenectomy. • The vascular resection during pancreaticoduodenectomy might be predictive of major complications. • Body morphometric analysis might be helpful for identifying high-risk patients.
OBJECTIVE: To evaluate predictive values of sarcopenia and visceral obesity measured from preoperative CT/MRIs for postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy in patients with periampullary malignancies. METHODS: From the prospectively constructed surgical registry, we included adult patients treated with pancreaticoduodenectomy. Based on CT/MRIs, body morphometric analysis was performed to evaluate the visceral obesity and sarcopenia, based on the areas of visceral fat and skeletal muscle measured at the L3 vertebrae level. We retrieved various perioperative factors from registry. As outcomes of postoperative complications, we evaluated POPF and major complications based on the Clavien-Dindo classification. Multivariate logistic regression analyses were performed. RESULTS: From a total of 284 patients (163 males, 121 females) who met the inclusion/exclusion criteria, POPF, major complications, and 60-day mortality occurred in 52 (18.3%), 34 (12.0%), and 6 (2.1%), respectively. Sarcopenia and visceral obesity were noted in 123 (75.5%) and 66 (40.5%) of men and 68 (56.2%) and 53 (43.8%) of women, respectively. Combination of sarcopenia and obesity (sarcopenic obesity) was noted in 31.9% (52/163) of men and in 26.4% (32/121) of women. In multivariate logistic regression analyses, sarcopenic obesity was the only independent predictor for POPF (OR 2.65, 95% CI 1.43-4.93), and the vascular resection during pancreaticoduodenectomy was the only independent predictor for severe complications (OR 3.75, 95% CI 1.61-8.70). CONCLUSION:Sarcopenic obesity might be highly predictive for POPF. Body morphometric analysis in preoperative CT/MRI combined with assessment of perioperative clinical features may help to identify high-risk patients and determine perioperative management strategies. KEY POINTS: • Sarcopenic obesity might be predictive for postoperative pancreatic fistula after pancreaticoduodenectomy. • The vascular resection during pancreaticoduodenectomy might be predictive of major complications. • Body morphometric analysis might be helpful for identifying high-risk patients.
Authors: N Pecorelli; G Carrara; F De Cobelli; G Cristel; A Damascelli; G Balzano; L Beretta; M Braga Journal: Br J Surg Date: 2016-01-18 Impact factor: 6.939
Authors: Marco Braga; Giovanni Capretti; Nicolò Pecorelli; Gianpaolo Balzano; Claudio Doglioni; Riccardo Ariotti; Valerio Di Carlo Journal: Ann Surg Date: 2011-11 Impact factor: 12.969
Authors: Robert D Boutin; Justin M Kaptuch; Cyrus P Bateni; James S Chalfant; Lawrence Yao Journal: AJR Am J Roentgenol Date: 2016-08-24 Impact factor: 3.959
Authors: Benjamin H L Tan; Laura A Birdsell; Lisa Martin; Vickie E Baracos; Kenneth C H Fearon Journal: Clin Cancer Res Date: 2009-11-03 Impact factor: 12.531
Authors: Song Hui Jia; Yue Li; Jean Parodo; Andras Kapus; Lingzhi Fan; Ori D Rotstein; John C Marshall Journal: J Clin Invest Date: 2004-05 Impact factor: 14.808
Authors: Andre E Modesto; Charlotte E Stuart; Jaelim Cho; Juyeon Ko; Ruma G Singh; Maxim S Petrov Journal: Eur Radiol Date: 2020-02-10 Impact factor: 5.315