Literature DB >> 30402785

Enhanced Desorption Electrospray Ionization Mass Spectrometry via Synchronizing Ion Generation and Ion Injection.

Zhuanghao Hou1, Xingchuang Xiong2, Xiang Fang3, Guangming Huang4,5.   

Abstract

A modified version of desorption electrospray ionization mass spectrometry was developed for (i) better utilization of analyte ions and (ii) larger sampling area via synchronization the pulsed nebulizer gas with ion injection. To synchronize the sheath gas, gas flow was paused for 50 ms within each cycle, leading to solvent accumulation at the end of emitter tip. That solvent accumulation enlarged the desorption areas. As a result, the amount of analytes increased. Thus, the improved signal intensity (~ 2-5-folds for various substrates) was benefit from both better analyte ion utilization and larger desorption areas. Finally, the enhanced signal intensity was confirmed with both garlic homogenate and brain homogenate. Graphical Abstract ᅟ.

Entities:  

Keywords:  Ion generation; Ion injection; Mass spectrometer; Signal enhancement; Synchronized desorption electrospray ionization

Year:  2018        PMID： 30402785     DOI： 10.1007/s13361-018-2082-z

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  25 in total

1.  Trace detection of non-uniformly distributed analytes on surfaces using mass transfer and large-area desorption electrospray ionization (DESI) mass spectrometry.

Authors:  Santosh Soparawalla; Gary A Salazar; Ewa Sokol; Richard H Perry; R Graham Cooks
Journal:  Analyst       Date:  2010-06-10       Impact factor: 4.616

2.  An innovative method based on quick, easy, cheap, effective, rugged, and safe extraction coupled to desorption electrospray ionization-high resolution mass spectrometry for screening the presence of paralytic shellfish toxins in clams.

Authors:  Monica Mattarozzi; Federica Bianchi; Marco Milioli; Antonella Cavazza; Maria Careri
Journal:  Talanta       Date:  2015-10-20       Impact factor: 6.057

3.  Pharmaceutical cleaning validation using non-proximate large-area desorption electrospray ionization mass spectrometry.

Authors:  Santosh Soparawalla; Gary A Salazar; Richard H Perry; Mark Nicholas; R Graham Cooks
Journal:  Rapid Commun Mass Spectrom       Date:  2009-01       Impact factor: 2.419

4.  Synchronized inductive desorption electrospray ionization mass spectrometry.

Authors:  Guangming Huang; Guangtao Li; Jason Ducan; Zheng Ouyang; R Graham Cooks
Journal:  Angew Chem Int Ed Engl       Date:  2011-02-18       Impact factor: 15.336

5.  Ammonium Bicarbonate Addition Improves the Detection of Proteins by Desorption Electrospray Ionization Mass Spectrometry.

Authors:  Elahe Honarvar; Andre R Venter
Journal:  J Am Soc Mass Spectrom       Date:  2017-03-17       Impact factor: 3.109

6.  Desorption electrospray ionisation mass spectrometry and tandem mass spectrometry of low molecular weight synthetic polymers.

Authors:  Anthony T Jackson; Jonathan P Williams; James H Scrivens
Journal:  Rapid Commun Mass Spectrom       Date:  2006       Impact factor: 2.419

7.  Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry.

Authors:  Mohammadreza Shariatgorji; Nicole Strittmatter; Anna Nilsson; Patrik Källback; Alexandra Alvarsson; Xiaoqun Zhang; Theodosia Vallianatou; Per Svenningsson; Richard J A Goodwin; Per E Andren
Journal:  Neuroimage       Date:  2016-05-04       Impact factor: 6.556

8.  Desorption electrospray ionization mass spectrometry for the analysis of pharmaceuticals and metabolites.

Authors:  Tiina J Kauppila; Justin M Wiseman; Raimo A Ketola; Tapio Kotiaho; R Graham Cooks; Risto Kostiainen
Journal:  Rapid Commun Mass Spectrom       Date:  2006       Impact factor: 2.419

9.  Cryo-sectioning of mice for whole-body imaging of drugs and metabolites with desorption electrospray ionization mass spectrometry imaging - a simplified approach.

Authors:  Seda Okutan; Harald S Hansen; Christian Janfelt
Journal:  Proteomics       Date:  2016-05-13       Impact factor: 3.984

10.  Synchronized Desorption Electrospray Ionization Mass Spectrometry Imaging.

Authors:  Troy J Comi; Seung Woo Ryu; Richard H Perry
Journal:  Anal Chem       Date:  2015-12-24       Impact factor: 6.986
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