Literature DB >> 30397891

Synthesis of Proteins Encoded by the Early Genes E2, E6, and E7 of Papillomavirus of Type 16 in the Plant Expression System.

R K Salyaev1,2, N I Rekoslavskaya3,4, A S Stolbikov3,4.   

Abstract

An expression system for the synthesis of early antigenic proteins HPV16 E2, HPV16 E6, and HPV16 E7 of high-risk papillomavirus based on transgenic tomato fruits was developed. It is planned to use the early antigenic proteins synthesized to create a therapeutic vaccine against cervical cancer.

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Year:  2018        PMID： 30397891     DOI： 10.1134/S1607672918050113

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  6 in total

1.  Retention of the ability to synthesize HIV-1 and HBV antigens in generations of tomato plants transgenic for the TBI-HBS gene.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov; R W Hammond; S N Shchelkunov
Journal:  Dokl Biochem Biophys       Date:  2009 Mar-Apr       Impact factor: 0.788

2.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors:  M M Bradford
Journal:  Anal Biochem       Date:  1976-05-07       Impact factor: 3.365

3.  Candidate mucosal vaccine against hepatitis B based on tomatoes transgenic for the preS2-S gene.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov; A V Tret'yakova
Journal:  Dokl Biochem Biophys       Date:  2012-11-07       Impact factor: 0.788

4.  Using the omega leader sequence of tobacco mosaic virus to transform tomato fruits with the papillomavirus hpv16 L1 gene to enhance production of the antigenic protein HPV16 L11.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov; A V Tret'yakova
Journal:  Dokl Biochem Biophys       Date:  2016-07-15       Impact factor: 0.788

5.  The study of immunogenicity of the antigenic protein of high risk oncogenic type of the human papillomavirus HPV16 L1 produced in the plant expression system on the base of transgenic tomato.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov; A V Tretyakova
Journal:  Dokl Biochem Biophys       Date:  2017-07-20       Impact factor: 0.788

Review 6.  Oncogenic activities of human papillomaviruses.

Authors:  Margaret E McLaughlin-Drubin; Karl Münger
Journal:  Virus Res       Date:  2009-06-18       Impact factor: 3.303
  6 in total
  2 in total

1.  The Induction of the Synthesis of Interferon, CD4 and CD8 T Lymphocytes in Blood and Spleen of Mice after Oral Vaccination with the "Early" Protein HPV16 E2.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov
Journal:  Dokl Biochem Biophys       Date:  2019-11-25       Impact factor: 0.788

2.  The Antiproliferative Effect of the "Early" Protein E2 of Papillomavirus HPV16 on Testis Tumors of Mice Induced by the Injection of HeLa Cells.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov
Journal:  Dokl Biochem Biophys       Date:  2019-11-25       Impact factor: 0.788
  2 in total

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