Literature DB >> 28726109

The study of immunogenicity of the antigenic protein of high risk oncogenic type of the human papillomavirus HPV16 L1 produced in the plant expression system on the base of transgenic tomato.

R K Salyaev1, N I Rekoslavskaya2,3, A S Stolbikov2, A V Tretyakova2.   

Abstract

The immunogenicity of plant-made peroral vaccine against cervical cancer was studied in mice during 342 days after vaccination with the material of tomato fruits genetically transformed with HPV16 L1 Ώ 5'UTR TMV. The immune response was found on day 4 after vaccination in blood serum of vaccinated mice. On days 90-100, the rise to maximum value of the level of antibodies to HPV16 L1 was in the range of 500 ng of the standard antibodies to HPV16 L1 (Santa Cruz Biotechnology, United States). This level of antibodies was retained until the end of the study.

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Year:  2017        PMID： 28726109     DOI： 10.1134/S1607672917030140

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  3 in total

1.  Using the omega leader sequence of tobacco mosaic virus to transform tomato fruits with the papillomavirus hpv16 L1 gene to enhance production of the antigenic protein HPV16 L11.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov; A V Tret'yakova
Journal:  Dokl Biochem Biophys       Date:  2016-07-15       Impact factor: 0.788

Review 2.  Therapy of human papillomavirus-related disease.

Authors:  Peter L Stern; Sjoerd H van der Burg; Ian N Hampson; Thomas R Broker; Alison Fiander; Charles J Lacey; Henry C Kitchener; Mark H Einstein
Journal:  Vaccine       Date:  2012-11-20       Impact factor: 3.641

Review 3.  When plant virology met Agrobacterium: the rise of the deconstructed clones.

Authors:  Hadrien Peyret; George P Lomonossoff
Journal:  Plant Biotechnol J       Date:  2015-06-12       Impact factor: 9.803
  3 in total
  2 in total

1.  Synthesis of Proteins Encoded by the Early Genes E2, E6, and E7 of Papillomavirus of Type 16 in the Plant Expression System.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov
Journal:  Dokl Biochem Biophys       Date:  2018-11-05       Impact factor: 0.788

2.  Cross-reactivity of antigens and antibodies belonging to different pathogenic types of human papillomaviruses.

Authors:  R K Salyaev; N I Rekoslavskaya; A S Stolbikov
Journal:  Dokl Biochem Biophys       Date:  2018-01-03       Impact factor: 0.788
  2 in total

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