Literature DB >> 30391472

Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets.

Werna T Uniken Venema1, Michiel D Voskuil1, Arnau Vich Vila2, Gerben van der Vries3, Bernadien H Jansen1, Bana Jabri4, Klaas Nico Faber5, Gerard Dijkstra1, Ramnik J Xavier6, Cisca Wijmenga3, Daniel B Graham6, Rinse K Weersma1, Eleonora A Festen7.   

Abstract

Entities:  

Keywords:  Genetics; Genome-wide Association Study; Immune Response; Inflammatory Bowel Disease

Mesh：

Substances：

Year:  2018        PMID： 30391472      PMCID： PMC6759855          DOI： 10.1053/j.gastro.2018.10.046

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


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  4 in total

1.  Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

Authors:  Jimmy Z Liu; Suzanne van Sommeren; Hailiang Huang; Siew C Ng; Rudi Alberts; Atsushi Takahashi; Stephan Ripke; James C Lee; Luke Jostins; Tejas Shah; Shifteh Abedian; Jae Hee Cheon; Judy Cho; Naser E Dayani; Lude Franke; Yuta Fuyuno; Ailsa Hart; Ramesh C Juyal; Garima Juyal; Won Ho Kim; Andrew P Morris; Hossein Poustchi; William G Newman; Vandana Midha; Timothy R Orchard; Homayon Vahedi; Ajit Sood; Joseph Y Sung; Reza Malekzadeh; Harm-Jan Westra; Keiko Yamazaki; Suk-Kyun Yang; Jeffrey C Barrett; Behrooz Z Alizadeh; Miles Parkes; Thelma Bk; Mark J Daly; Michiaki Kubo; Carl A Anderson; Rinse K Weersma
Journal:  Nat Genet       Date:  2015-07-20       Impact factor: 41.307

2.  Genetic and epigenetic fine mapping of causal autoimmune disease variants.

Authors:  Kyle Kai-How Farh; Alexander Marson; Jiang Zhu; Markus Kleinewietfeld; William J Housley; Samantha Beik; Noam Shoresh; Holly Whitton; Russell J H Ryan; Alexander A Shishkin; Meital Hatan; Marlene J Carrasco-Alfonso; Dita Mayer; C John Luckey; Nikolaos A Patsopoulos; Philip L De Jager; Vijay K Kuchroo; Charles B Epstein; Mark J Daly; David A Hafler; Bradley E Bernstein
Journal:  Nature       Date:  2014-10-29       Impact factor: 49.962

3.  Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

Authors:  Tim Raine; Jimmy Z Liu; Carl A Anderson; Miles Parkes; Arthur Kaser
Journal:  Gut       Date:  2014-05-05       Impact factor: 23.059

4.  Massively parallel digital transcriptional profiling of single cells.

Authors:  Grace X Y Zheng; Jessica M Terry; Phillip Belgrader; Paul Ryvkin; Zachary W Bent; Ryan Wilson; Solongo B Ziraldo; Tobias D Wheeler; Geoff P McDermott; Junjie Zhu; Mark T Gregory; Joe Shuga; Luz Montesclaros; Jason G Underwood; Donald A Masquelier; Stefanie Y Nishimura; Michael Schnall-Levin; Paul W Wyatt; Christopher M Hindson; Rajiv Bharadwaj; Alexander Wong; Kevin D Ness; Lan W Beppu; H Joachim Deeg; Christopher McFarland; Keith R Loeb; William J Valente; Nolan G Ericson; Emily A Stevens; Jerald P Radich; Tarjei S Mikkelsen; Benjamin J Hindson; Jason H Bielas
Journal:  Nat Commun       Date:  2017-01-16       Impact factor: 14.919
  4 in total
  20 in total

1.  T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer.

Authors:  Michael L Washburn; Zhang Wang; Andrew H Walton; S Peter Goedegebuure; David J Figueroa; Stephanie Van Horn; Julie Grossman; Katja Remlinger; Heather Madsen; James Brown; Roopa Srinivasan; Amaya I Wolf; Scott B Berger; Victoria N Yi; William G Hawkins; Ryan C Fields; Richard S Hotchkiss
Journal:  J Immunol       Date:  2019-09-04       Impact factor: 5.422

2.  Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection.

Authors:  Carolyn Bomidi; Matthew Robertson; Cristian Coarfa; Mary K Estes; Sarah E Blutt
Journal:  Proc Natl Acad Sci U S A       Date:  2021-11-09       Impact factor: 11.205

3.  Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells.

Authors:  Jayne E Wiarda; Julian M Trachsel; Sathesh K Sivasankaran; Christopher K Tuggle; Crystal L Loving
Journal:  Life Sci Alliance       Date:  2022-08-22

Review 4.  Machine Learning Predictive Outcomes Modeling in Inflammatory Bowel Diseases.

Authors:  Aamir Javaid; Omer Shahab; William Adorno; Philip Fernandes; Eve May; Sana Syed
Journal:  Inflamm Bowel Dis       Date:  2022-06-03       Impact factor: 7.290

Review 5.  Use of Single-Cell -Omic Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features.

Authors:  Mirazul Islam; Bob Chen; Jeffrey M Spraggins; Ryan T Kelly; Ken S Lau
Journal:  Gastroenterology       Date:  2020-05-14       Impact factor: 22.682

Review 6.  Epigenomic and transcriptomic analysis of chronic inflammatory diseases.

Authors:  Sabrina Ka Man Tam; Danny Chi Yeu Leung
Journal:  Genes Genomics       Date:  2021-02-27       Impact factor: 1.839

7.  Integrated Bioinformatics Analysis Identifies ELAVL1 and APP as Candidate Crucial Genes for Crohn's Disease.

Authors:  Heli Li; Qianru Li; Shiran Sun; Ping Lei; Xiong Cai; Guanxin Shen
Journal:  J Immunol Res       Date:  2020-07-17       Impact factor: 4.818

Review 8.  Molecular Profiling of Inflammatory Bowel Disease: Is It Ready for Use in Clinical Decision-Making?

Authors:  Ho-Su Lee; Isabelle Cleynen
Journal:  Cells       Date:  2019-06-04       Impact factor: 6.600

9.  Differential Pathogenic Th17 Profile in Mesenteric Lymph Nodes of Crohn's Disease and Ulcerative Colitis Patients.

Authors:  Marwa Bsat; Laurence Chapuy; Manuel Rubio; Ramses Wassef; Carole Richard; Frank Schwenter; Rasmy Loungnarath; Geneviève Soucy; Heena Mehta; Marika Sarfati
Journal:  Front Immunol       Date:  2019-05-28       Impact factor: 7.561

10.  Expression Quantitative Trait Loci (eQTL) Mapping in Korean Patients With Crohn's Disease and Identification of Potential Causal Genes Through Integration With Disease Associations.

Authors:  Seulgi Jung; Wenting Liu; Jiwon Baek; Jung Won Moon; Byong Duk Ye; Ho-Su Lee; Sang Hyoung Park; Suk-Kyun Yang; Buhm Han; Jianjun Liu; Kyuyoung Song
Journal:  Front Genet       Date:  2020-05-14       Impact factor: 4.599
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