| Literature DB >> 26192919 |
Jimmy Z Liu1, Suzanne van Sommeren2,3, Hailiang Huang4, Siew C Ng5, Rudi Alberts2, Atsushi Takahashi6, Stephan Ripke4, James C Lee7, Luke Jostins8, Tejas Shah1, Shifteh Abedian9, Jae Hee Cheon10, Judy Cho11, Naser E Dayani12, Lude Franke3, Yuta Fuyuno13, Ailsa Hart14, Ramesh C Juyal15, Garima Juyal16, Won Ho Kim10, Andrew P Morris17, Hossein Poustchi9, William G Newman18, Vandana Midha19, Timothy R Orchard20, Homayon Vahedi9, Ajit Sood19, Joseph Y Sung5, Reza Malekzadeh9, Harm-Jan Westra3, Keiko Yamazaki13, Suk-Kyun Yang21, Jeffrey C Barrett1, Behrooz Z Alizadeh22, Miles Parkes7, Thelma Bk16, Mark J Daly4, Michiaki Kubo13, Carl A Anderson1, Rinse K Weersma2.
Abstract
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease (IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and Immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. We implicate 38 loci in IBD risk for the first time. For the majority of the IBD risk loci, the direction and magnitude of effect are consistent in European and non-European cohorts. Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM). Our results provide biological insights into the pathogenesis of IBD and demonstrate the usefulness of trans-ancestry association studies for mapping loci associated with complex diseases and understanding genetic architecture across diverse populations.Entities:
Mesh：
Year: 2015 PMID： 26192919 PMCID： PMC4881818 DOI： 10.1038/ng.3359
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307