Literature DB >> 30373805

Vaginal Gel Component Hydroxyethyl Cellulose Significantly Enhances the Infectivity of Chlamydia trachomatis Serovars D and E.

Tímea Raffai1, Katalin Burián1, László Janovák2, Anita Bogdanov1, Johannes H Hegemann3, Valéria Endrész1, Dezső P Virok4.   

Abstract

The transmission of the urogenital serovars of Chlamydia trachomatis can be significantly influenced by vaginal gels. Hydroxyethyl cellulose is a commonly used gelling agent that can be found in vaginal gels. Hydroxyethyl cellulose showed a concentration-dependent growth-enhancing effect on C. trachomatis serovars D and E, with a 26.1-fold maximal increase in vitro and a 2.57-fold increase in vivo.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Chlamydia trachomatiszzm321990; hydroxyethyl cellulose; infectivity; vaginal gel

Mesh：

Substances：

Year:  2018        PMID： 30373805      PMCID： PMC6325178          DOI： 10.1128/AAC.02034-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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Journal:  Contraception       Date:  1999-02       Impact factor: 3.375

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4.  Interaction of Chlamydia trachomatis organisms and HeLa 229 cells.

Authors:  C C Kuo; T Grayston
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5.  Semi-solid gels function as physical barriers to human immunodeficiency virus transport in vitro.

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Authors:  Xing Gao; Xiang-Sheng Chen; Yue-Ping Yin; Ming-Ying Zhong; Mei-Qin Shi; Wan-Hui Wei; Qiang Chen; Rosanna W Peeling; David Mabey
Journal:  J Clin Microbiol       Date:  2007-02-14       Impact factor: 5.948

7.  Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity.

Authors:  Ali A Abdul Sater; David M Ojcius; Matthew P Meyer
Journal:  Antimicrob Agents Chemother       Date:  2008-04-14       Impact factor: 5.191

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9.  Genome sequencing of Chlamydia trachomatis serovars E and F reveals substantial genetic variation.

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Review 10.  Influence of the tryptophan-indole-IFNγ axis on human genital Chlamydia trachomatis infection: role of vaginal co-infections.

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Journal:  Front Cell Infect Microbiol       Date:  2014-06-03       Impact factor: 5.293
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1.  Correlation between detergent activity and anti-herpes simplex virus-2 activity of commercially available vaginal gels.

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2.  Bioactive Compounds of Nigella Sativa Essential Oil as Antibacterial Agents against Chlamydia Trachomatis D.

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