Literature DB >> 18411317

Susceptibility of Chlamydia trachomatis to the excipient hydroxyethyl cellulose: pH and concentration dependence of antimicrobial activity.

Ali A Abdul Sater1, David M Ojcius, Matthew P Meyer.   

Abstract

Hydroxyethyl cellulose (HEC) is used as a neutral excipient in microbicides used against sexually transmitted pathogens. However, HEC inhibits the infection of cervical epithelial cells by Chlamydia trachomatis at pH 5 in a concentration-dependent manner. At pH 7, infection is inversely dependent on the concentration of HEC, possibly due to pH-dependent calcium sequestration.

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Year:  2008        PMID： 18411317      PMCID： PMC2443922          DOI： 10.1128/AAC.00785-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Design of a "microbicide" for prevention of sexually transmitted diseases using "inactive" pharmaceutical excipients.

Authors:  A R Neurath; N Strick; Y Y Li; K Lin; S Jiang
Journal:  Biologicals       Date:  1999-03       Impact factor: 1.856

Review 2.  Global prevalence and incidence estimates of selected curable STDs.

Authors:  A C Gerbase; J T Rowley; D H Heymann; S F Berkley; P Piot
Journal:  Sex Transm Infect       Date:  1998-06       Impact factor: 3.519

3.  Susceptibility of Chlamydia trachomatis to excipients commonly used in topical microbicide formulations.

Authors:  M F Lampe; L C Rohan; M C Skinner; W E Stamm
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

Review 4.  A review on infection with Chlamydia trachomatis.

Authors:  Kaveh Manavi
Journal:  Best Pract Res Clin Obstet Gynaecol       Date:  2006-08-24       Impact factor: 5.237

5.  Killing of Chlamydia trachomatis by novel antimicrobial lipids adapted from compounds in human breast milk.

Authors:  M F Lampe; L M Ballweber; C E Isaacs; D L Patton; W E Stamm
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

6.  Chlamydia trachomatis OmcB protein is a surface-exposed glycosaminoglycan-dependent adhesin.

Authors:  Sanaa Fadel; Adrian Eley
Journal:  J Med Microbiol       Date:  2007-01       Impact factor: 2.472

7.  Mechanism by which calcium phosphate coprecipitation enhances adenovirus-mediated gene transfer.

Authors:  R Walters; M Welsh
Journal:  Gene Ther       Date:  1999-11       Impact factor: 5.250

8.  Basic calcium phosphate crystals stimulate the endocytotic activity of cells--inhibition by anti-calcification agents.

Authors:  Yubo Sun; Xiao-Rong Zeng; Leonor Wenger; Herman S Cheung
Journal:  Biochem Biophys Res Commun       Date:  2003-12-26       Impact factor: 3.575

9.  Protection against Chlamydia trachomatis infection in vitro and modulation of inflammatory response in vivo by membrane-bound glycosaminoglycans.

Authors:  Toni Darville; Saul Yedgar; M Krimsky; C W Andrews; Thomas Jungas; David M Ojcius
Journal:  Microbes Infect       Date:  2004-04       Impact factor: 2.700

10.  Effects of chemically modified heparin on Chlamydia trachomatis serovar L2 infection of eukaryotic cells in culture.

Authors:  Hiromitsu Yabushita; Yasuyuki Noguchi; Hiroko Habuchi; Satoko Ashikari; Ken Nakabe; Masaru Fujita; Masayoshi Noguchi; Jeffrey D Esko; Koji Kimata
Journal:  Glycobiology       Date:  2002-05       Impact factor: 4.313
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  2 in total

1.  An automated image-based method for rapid analysis of Chlamydia infection as a tool for screening antichlamydial agents.

Authors:  Ichie Osaka; Jeffrey M Hills; Sarah L Kieweg; Heather E Shinogle; David S Moore; P Scott Hefty
Journal:  Antimicrob Agents Chemother       Date:  2012-05-21       Impact factor: 5.191

2.  Vaginal Gel Component Hydroxyethyl Cellulose Significantly Enhances the Infectivity of Chlamydia trachomatis Serovars D and E.

Authors:  Tímea Raffai; Katalin Burián; László Janovák; Anita Bogdanov; Johannes H Hegemann; Valéria Endrész; Dezső P Virok
Journal:  Antimicrob Agents Chemother       Date:  2018-12-21       Impact factor: 5.191
  2 in total

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